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BenjMurrell's profile
Ben Murrell
Ben Murrell
Ben Murrell
@BenjMurrell

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Ben Murrell

@BenjMurrell

Researcher at Karolinska. Viruses. Antibodies. Sequencing. Assaying. Modelling. Computing. Work used to be dry, but is now often wet.

Karolinska, Stockholm
scholar.google.com/citations?user…
Joined December 2021

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    1. Ben Murrell‏ @BenjMurrell 7 Dec 2021

      Omicron antibody neutralization thread, with preliminary results, and substantial caveats. Most credit to @DannySheward. We’ve been racing to generate neutralization data as fast as possible, and our first results were read this afternoon (1/n).

      51 replies 674 retweets 2,061 likes
      Show this thread
    2. Ben Murrell‏ @BenjMurrell 7 Dec 2021

      Major NB: this is preliminary data. Given the circumstances, however, we feel it critical to release data right away, and explain current caveats that we can later iron out and investigate. Link here: https://tinyurl.com/ycx4x4d4  (2/n).

      7 replies 58 retweets 325 likes
      Show this thread
    3. Ben Murrell‏ @BenjMurrell 7 Dec 2021

      Summary: In our hands, from a first set of results, the loss of neutralization against Omicron (relative to the pandemic founder) is exceptionally variable, with some samples showing almost no loss, and some showing ±25-fold loss relative to the pandemic founder variant (3/n).pic.twitter.com/bitqb2zoXO

      4 replies 111 retweets 396 likes
      Show this thread
      Ben Murrell‏ @BenjMurrell 7 Dec 2021

      The average loss of neutralization potency was lower than feared. For example, in a cohort of 17 random blood donors, the mean fold-reduction was around 7 (trying to account for censoring), making it certainly worse than Delta, but, again, not as extreme as we expected (4/n)pic.twitter.com/O6nY3PHcX6

      2:07 PM - 7 Dec 2021
      • 204 Retweets
      • 737 Likes
      • Sofia Brak Shabby Tigers El Demiurgo Mike D Consuelo فرعون Poppy McCorn Sheila Shin ขายหน้ากากอนามัย KF94
      12 replies 204 retweets 737 likes
        1. New conversation
        2. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          This was measured by a “pseudovirus assay”, which is one of the standard approaches for characterising antibody neutralization potency - the other being assays with live virus (5/n)

          3 replies 26 retweets 253 likes
          Show this thread
        3. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          In parallel, researchers in South Africa (@sigallab) have been working on live virus neutralization assays, and their results show a much more substantial average reduction (6/n)

          2 replies 43 retweets 315 likes
          Show this thread
        4. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          While the magnitude differs between our results and theirs, what is common is that neutralization is not completely lost for all samples, which is positive (7/n)

          1 reply 36 retweets 378 likes
          Show this thread
        5. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          There are many possible explanations for the differences between our results and those @sigallab. Primarily, the patient cohorts were from different continents with different exposure histories (8/n)

          4 replies 29 retweets 271 likes
          Show this thread
        6. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          Perhaps corroborating this view: a “WHO neutralization standard”, which is a pool of early plasma samples used to standardize these assays, showed a 40-fold loss of neutralization potency against Omicron relative to the founder variant in our assay (9/n)

          2 replies 36 retweets 272 likes
          Show this thread
        7. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          There are also multiple technical differences attributable to the assays themselves. We hope to learn more as results come in from all over the world (10/n)

          1 reply 15 retweets 194 likes
          Show this thread
        8. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          In the coming days, we will be repeating these assays, and attempting to deepen our understanding of the neutralisation resistance of Omicron, as well including other variants, which will help contextualise this (11/n)

          4 replies 15 retweets 217 likes
          Show this thread
        9. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          Key to all of this was the early sharing of data from South Africa (driven by @Tuliodna), and the identification of S-gene target failures as a means of screening for Omicron samples, which is now used globally (12/n)

          7 replies 55 retweets 454 likes
          Show this thread
        10. Ben Murrell‏ @BenjMurrell 7 Dec 2021

          On our side, @DannySheward has been exceptional in all this, as have key collaborators @NillaKH @AlecPnkw, and especially @Jan_Albert_ and his team for rapidly identifying and sharing a set of anonymised samples from suspected Omicron cases (13/n)

          18 replies 19 retweets 271 likes
          Show this thread
        11. End of conversation
        1. New conversation
        2. S.K.‏ @ack_fan 7 Dec 2021
          Replying to @BenjMurrell @andrew_croxford

          is this another study from the one reported earlier?Hopium!

          1 reply 0 retweets 2 likes
        3. Mike Dee‏ @MikeDeeeeeee 7 Dec 2021
          Replying to @ack_fan @BenjMurrell @andrew_croxford

          yes, completely different.

          0 replies 0 retweets 6 likes
        4. End of conversation

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