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BallouxFrancois's profile
Prof Francois Balloux
Prof Francois Balloux
Prof Francois Balloux
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@BallouxFrancois

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Prof Francois BallouxVerified account

@BallouxFrancois

Director @UGI_at_UCL. Militant corona-centrist

Where snow is powdery and deep
scholar.google.co.uk/citations?user…
Joined April 2019

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    1. zeynep tufekci‏Verified account @zeynep 27 Sep 2021

      Do people know that the 1890 pandemic was likely caused by another coronavirus, OC43 (that was then novel?) Nowadays, no longer novel, it is one of the causes of the common cold. We're obviously not living in the OC43 pandemic since, and we won't live in a COVID pandemic forever.

      103 replies 542 retweets 2,757 likes
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      Prof Francois Balloux‏Verified account @BallouxFrancois 27 Sep 2021
      Replying to @zeynep

      The 1890/91 'Russian flu' having 'likely' been caused by HCoV-OC43 may be a bit too strong s statement. It is not implausible that the 1890/91 'Russian flu' was caused by one of the current endemic coronaviruses, though OC43 may not be the best candidate. 1/

      10:01 AM - 27 Sep 2021
      • 15 Retweets
      • 131 Likes
      • Bradley Yount, MHS, PA-C Randall Parker #VaccinesForMoreViruses Ammar Mikael Niku Ore Carmi Sally Provan Patrick Boland loki maelorin 🏳️‍⚧️🏳️‍🌈 (they) everythingism
      5 replies 15 retweets 131 likes
        1. New conversation
        2. Prof Francois Balloux‏Verified account @BallouxFrancois 27 Sep 2021
          Replying to @BallouxFrancois @zeynep

          HCoV-NL63 may actually be a more plausible candidate for the 1890/91 pandemic for a a series of reasons, including: - NL63 uses the same ACE2 host cell receptor, which leads to fairly systemic infections - NL63 is a bit more virulent than OC43 2/

          3 replies 8 retweets 70 likes
        3. Prof Francois Balloux‏Verified account @BallouxFrancois 27 Sep 2021
          Replying to @BallouxFrancois @zeynep

          - When we estimate the time to the 'Most Recent Common Ancestor' using all HCoV genomes available, we get a date largely compatible with a late 19th century host jump into humans for NL63, whereas it is more recent for OC43. 3/ Credit: Charlotte Jenner and @LucyvanDorppic.twitter.com/r7HAyvggI9

          5 replies 5 retweets 65 likes
        4. Show replies
        1. New conversation
        2. Paul Nuki‏Verified account @PaulNuki 27 Sep 2021
          Replying to @BallouxFrancois @zeynep

          I think I read that someone was trying to track down samples to shed better light on this. Has that happened yet?

          1 reply 1 retweet 7 likes
        3. Prof Francois Balloux‏Verified account @BallouxFrancois 27 Sep 2021
          Replying to @PaulNuki @zeynep

          We're trying, still without success so far. In case you had some lung tissue in a jar dating back the late 19th century lying around, please let me know ...

          6 replies 3 retweets 75 likes
        4. Show replies
        1. Federico Gueli‏ @bicidiario 27 Sep 2021
          Replying to @BallouxFrancois @zeynep

          it would be important to know if oc43 furin cleavage site was active at time of the spillover or not.

          0 replies 0 retweets 2 likes
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        1. New conversation
        2. Paul Jakma‏ @pjakma 27 Sep 2021
          Replying to @BallouxFrancois @zeynep

          Could it also be influenza? I was reading an old 'original antigenic sin' paper other day which contained some observations of evidence of neutralising antibodies in old people that suggested an influenza epidemic in the 1890s. I can dig up the paper tomorrow.

          2 replies 0 retweets 1 like
        3. Prof Francois Balloux‏Verified account @BallouxFrancois 27 Sep 2021
          Replying to @pjakma @zeynep

          The 1889/90 pandemic could have been caused by an influenza strain; an Influenza A H2N2 or H3N8 lineage have been both suggested as possible agents. It will probably remain an open question until we get decent genomes from the viruses that infected people at the time.

          2 replies 0 retweets 5 likes
        4. Show replies
        1. New conversation
        2. Tony‏ @TonyGoldSE 28 Sep 2021
          Replying to @BallouxFrancois @zeynep

          With these previous pandemics I wonder what the death toll have been if we'd mass tested asymptomatic people.

          1 reply 0 retweets 0 likes
        3. J Shepherd‏ @brainbootcamp 29 Sep 2021
          Replying to @TonyGoldSE @BallouxFrancois @zeynep

          Changes in all cause mortality would be more useful, if the historical records were complete.

          0 replies 0 retweets 1 like
        4. End of conversation

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