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BallouxFrancois's profile
Prof Francois Balloux
Prof Francois Balloux
Prof Francois Balloux
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@BallouxFrancois

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Prof Francois BallouxVerified account

@BallouxFrancois

Director @UGI_at_UCL. Militant corona-centrist

Where snow is powdery and deep
scholar.google.co.uk/citations?user…
Joined April 2019

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    Prof Francois Balloux‏Verified account @BallouxFrancois 22 May 2020

    There have been claims that #COVID19 has acquired mutations leading to more transmissible strains. We formally tested whether this was the case using 15,000 #SARSCoV2 genomes from all over the world: ... and the answer is no, not at all! (1/5) https://tinyurl.com/ycrgb7ad pic.twitter.com/NyHv3eq6BY

    1:17 AM - 22 May 2020
    • 1,917 Retweets
    • 3,352 Likes
    • Mark Thomas Lord Antinormal Discount Dave Samarth Patel LouBLou 🕷⚫️ #3.5% FBCoalition2024 #FBPE #Rejoiner Baba Ganoosh Javier Fortea Biotechase Dr Martin Opposes Gov’t Corruption
    50 replies 1,917 retweets 3,352 likes
      1. New conversation
      2. Prof Francois Balloux‏Verified account @BallouxFrancois 22 May 2020

        We analysed all mutations in the #SARSCoV2 genome that are plausible candidates for adaptation to its novel human host with a novel approach comparing the relative number of descendants of all sister lineages with and without a specific mutation. (2/5) https://tinyurl.com/ycrgb7ad pic.twitter.com/NC6gVivvpU

        7 replies 42 retweets 150 likes
        Show this thread
      3. Prof Francois Balloux‏Verified account @BallouxFrancois 22 May 2020

        No single mutation having emerged recurrently to this day is significantly associated with increased transmission of #SARSCoV2. Instead, all those mutations are neutral or deleterious to the virus' transmission, some significantly so. (3/5) https://tinyurl.com/ycrgb7ad pic.twitter.com/z5p6z26jKl

        8 replies 98 retweets 244 likes
        Show this thread
      4. Prof Francois Balloux‏Verified account @BallouxFrancois 22 May 2020

        Interestingly, the majority of recurrent mutations having emerged in #SARSCoV2 to date are not due to mistakes made by the virus during replication. Instead they were caused by the RNA editing machinery, which is part of our immune system. (4/5) https://tinyurl.com/ycrgb7ad pic.twitter.com/Imy9qaw17d

        14 replies 92 retweets 286 likes
        Show this thread
      5. Prof Francois Balloux‏Verified account @BallouxFrancois 22 May 2020

        It was a great honour and privilege to do this work in collaboration with a fantastic team of wonderfully talented scientists. Thank you @LucyvanDorp, Damien Richard, @liampshaw, @CedricCSTan1, @misac42. (5/5) https://tinyurl.com/ycrgb7ad pic.twitter.com/6DMa10GfvF

        16 replies 43 retweets 221 likes
        Show this thread
      6. End of conversation
      1. New conversation
      2. Natsicle‏ @natterlyk 22 May 2020
        Replying to @BallouxFrancois @KrisHolt1

        For a lay person, this is good news right?

        1 reply 0 retweets 10 likes
      3. Kris Holt‏ @KrisHolt1 22 May 2020
        Replying to @natterlyk

        Yes, if I’m understanding correctly, there’s no evidence supporting mutations that result in increased Covid transmissibility, and the mutations we are seeing are less efficient than the initial strain.

        2 replies 5 retweets 58 likes
      4. Show replies
      1. New conversation
      2. Oumaumua. Stay away from German Philosophers.‏ @oumaumua 22 May 2020
        Replying to @BallouxFrancois

        Are viruses this stable?

        1 reply 0 retweets 1 like
      3. LazyAnole‏ @TheLazyAnole 22 May 2020
        Replying to @oumaumua

        Depends on the virus. The flu virus mutates very quickly, which is why you need a new flu shot every year. Other viruses mutate much more slowly. This novel coronavirus is not as stable as measles, but so far it appears to mutate more slowly than the flu.

        0 replies 0 retweets 4 likes
      4. End of conversation
      1. Norman Lockhart‏ @drnlockhart 22 May 2020
        Replying to @BallouxFrancois

        The observed mutation rate is consistent with other RNA viruses.

        0 replies 1 retweet 5 likes
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      1. Norman Lockhart‏ @drnlockhart 22 May 2020
        Replying to @BallouxFrancois

        It seems that if a Cov19 mutation is not neutral (ie no selective effect) the change is mildly deleterious to the virus. The paper detects evidence that human-coded enzymes in the human cell are involved in producing these deleterious genetic changes - another layer of defence.

        0 replies 1 retweet 14 likes
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