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B_resnick's profile
Brian Resnick
Brian Resnick
Brian Resnick
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@B_resnick

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Brian ResnickVerified account

@B_resnick

Science reporter @voxdotcom: psychology, stars, nature, health, and “whoa that’s cool.” http://www.vox.com/authors/brian-resnick …

Washington, DC
brian-resnick.com
Joined May 2011

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    1. Brian Resnick‏Verified account @B_resnick Oct 22

      Genetics research is overwhelmingly conducted on white participants of European ancestry. That's a big problem for medicine. https://www.vox.com/science-and-health/2018/10/22/17983568/precision-medicine-genetics-gwas-diversity-all-of-us …pic.twitter.com/sNCxPGJUE3

      32 replies 72 retweets 142 likes
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    2. Brian Resnick‏Verified account @B_resnick Oct 22

      There is interesting debate over whether polygenic risk assesments will ever truly be clinically useful (beyond risk assesments conducted today.) But as it stands, those assesments won't be equitable, working on everyone.

      1 reply 0 retweets 2 likes
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    3. Brian Resnick‏Verified account @B_resnick Oct 22

      There are important things not to confuse here. Genetic risk scores derived from Europeans don't translate as well to other people. That's **not** because we're so biologically different. Or because race is a "biological construct."

      5 replies 0 retweets 2 likes
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      Brian Resnick‏Verified account @B_resnick Oct 22

      It's because the differences that signal risk from one group to a next, are teeny tiny, a bit arbitrary, and not always directly linked to the casual pathway that translates genes to disease.

      7:51 AM - 22 Oct 2018
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      • Gabriella Conti the Autistocrat Barney Pagani Michelle Maeve
      5 replies 1 retweet 4 likes
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        2. Brian Resnick‏Verified account @B_resnick Oct 22

          If anything, it's another example of how wonderfully complex our genomes are, how useful human variation can be, and how the small differences between us, though tiny, still can matter when it comes to health.

          3 replies 0 retweets 1 like
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        3. Brian Resnick‏Verified account @B_resnick Oct 22

          Anyway, thanks to @genetisaur and her colleagues for the chart above. And for helping to explain this problem to me.

          1 reply 0 retweets 2 likes
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        4. End of conversation
        1. Random Geezer‏ @DrMcCleod Oct 23
          Replying to @B_resnick

          I am not clear how this statement supports the first. What do you mean by 'group'?

          0 replies 0 retweets 1 like
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        1. Grodejar 🥛 👌🏻 🇺🇸 🗽‏ @grodejar Oct 23
          Replying to @B_resnick

          So race isn't real but it's racial differences that are the problem? That is some next level cognitive dissonance.

          0 replies 0 retweets 1 like
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        1. Neil Patrick Chasseur‏ @PL_Goldrush Oct 22
          Replying to @B_resnick

          Being immune to a crippling disease where another population group is vulnerable to it seems like it might not be "arbitrary" or "tiny"

          0 replies 0 retweets 1 like
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        1. Andrea Twerkin‏ @TwerkinAndrea Oct 25
          Replying to @B_resnick

          "teeny tiny" #ScienceBoy

          0 replies 0 retweets 0 likes
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