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B_resnick's profile
Brian Resnick
Brian Resnick
Brian Resnick
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@B_resnick

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Brian ResnickVerified account

@B_resnick

Science reporter @voxdotcom: psychology, stars, nature, health, and “whoa that’s cool.” http://www.vox.com/authors/brian-resnick …

Washington, DC
brian-resnick.com
Joined May 2011

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    Brian Resnick‏Verified account @B_resnick Oct 22

    Genetics research is overwhelmingly conducted on white participants of European ancestry. That's a big problem for medicine. https://www.vox.com/science-and-health/2018/10/22/17983568/precision-medicine-genetics-gwas-diversity-all-of-us …pic.twitter.com/sNCxPGJUE3

    7:47 AM - 22 Oct 2018
    • 72 Retweets
    • 142 Likes
    • Azor scott Carl Franzen Bis The fairy Tara McCarthy 🍂 marmagedon Katie Gordon Peter Bachman Emma C. Moore
    32 replies 72 retweets 142 likes
      1. New conversation
      2. Brian Resnick‏Verified account @B_resnick Oct 22

        There is interesting debate over whether polygenic risk assesments will ever truly be clinically useful (beyond risk assesments conducted today.) But as it stands, those assesments won't be equitable, working on everyone.

        1 reply 0 retweets 2 likes
        Show this thread
      3. Brian Resnick‏Verified account @B_resnick Oct 22

        There are important things not to confuse here. Genetic risk scores derived from Europeans don't translate as well to other people. That's **not** because we're so biologically different. Or because race is a "biological construct."

        5 replies 0 retweets 2 likes
        Show this thread
      4. Brian Resnick‏Verified account @B_resnick Oct 22

        It's because the differences that signal risk from one group to a next, are teeny tiny, a bit arbitrary, and not always directly linked to the casual pathway that translates genes to disease.

        5 replies 1 retweet 4 likes
        Show this thread
      5. Brian Resnick‏Verified account @B_resnick Oct 22

        If anything, it's another example of how wonderfully complex our genomes are, how useful human variation can be, and how the small differences between us, though tiny, still can matter when it comes to health.

        3 replies 0 retweets 1 like
        Show this thread
      6. Brian Resnick‏Verified account @B_resnick Oct 22

        Anyway, thanks to @genetisaur and her colleagues for the chart above. And for helping to explain this problem to me.

        1 reply 0 retweets 2 likes
        Show this thread
      7. End of conversation
      1. New conversation
      2. Tara McCarthy  🍂‏ @realitycalls8 Oct 22
        Replying to @B_resnick

        Whites are putting the most money into it, why shouldn't whites primarily benefit from it?

        2 replies 3 retweets 81 likes
      3. Brian Resnick‏Verified account @B_resnick Oct 22
        Replying to @realitycalls8

        I find this view to be deeply mean.

        15 replies 2 retweets 1 like
      4. Tara McCarthy  🍂‏ @realitycalls8 Oct 22
        Replying to @B_resnick

        You're just trying to communise science research, aren't you?

        2 replies 0 retweets 26 likes
      5. End of conversation
      1. New conversation
      2. Brian Resnick‏Verified account @B_resnick Oct 22
        Replying to @ADarkerTimeline

        It's not so surprising. But yet it is still a problem. I outline in the story.

        1 reply 0 retweets 2 likes
      3. End of conversation
      1. US of Post America‏ @USofPostAmerica Oct 22
        Replying to @B_resnick

        Wait is Vox publishing a graph showing Europeans to be a global minority?....Alt Right, Far Right, White Supremacist, Nazis!!!

        0 replies 2 retweets 20 likes
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      1. Major Tom‏ @firefly00001101 Oct 22
        Replying to @B_resnick

        Your source is @voxdotcom 🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🤣🙃

        0 replies 1 retweet 11 likes
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      1. New conversation
      2. robert ©alifornia‏ @WaukeSlosh Oct 22
        Replying to @B_resnick @voxdotcom

        I actually suggested this back in college, and the professor told me making the distinction of drugs’ impact between races was inherently racist

        1 reply 0 retweets 5 likes
      3.  🦃Anturkey Scaramucci 🦃‏ @itsbirdemic Oct 22
        Replying to @WaukeSlosh @B_resnick @voxdotcom

        Well because drug impact doesn't really vary by race is varies by ancestry (at relevant loci)

        2 replies 0 retweets 1 like
      4. Pale_Primate‏ @PALE_Primate Oct 23
        Replying to @itsbirdemic @WaukeSlosh and

        That's what race is. Populations that vary by ancestry.

        1 reply 0 retweets 4 likes
      5.  🦃Anturkey Scaramucci 🦃‏ @itsbirdemic Oct 23
        Replying to @PALE_Primate @WaukeSlosh and

        That is not what race is, race has an entirely different metaphysical basis than population. For one, populations are contextual and instrumental not natural descriptions of the world like race is intended to be.

        1 reply 0 retweets 1 like
      6. Pale_Primate‏ @PALE_Primate Oct 23
        Replying to @itsbirdemic @WaukeSlosh and

        Do white parents have white babies? Do black parents have black babies?

        1 reply 0 retweets 2 likes
      7.  🦃Anturkey Scaramucci 🦃‏ @itsbirdemic Oct 23
        Replying to @PALE_Primate @WaukeSlosh and

        That is neither a relevant question nor one that has any real meaning. "White" is not really a biological population nor is it an independent evolutionary lineage

        1 reply 0 retweets 1 like
      8. Pale_Primate‏ @PALE_Primate Oct 23
        Replying to @itsbirdemic @WaukeSlosh @B_resnick

        pic.twitter.com/c0ylzm9J1p

        1 reply 0 retweets 3 likes
      9.  🦃Anturkey Scaramucci 🦃‏ @itsbirdemic Oct 23
        Replying to @PALE_Primate @WaukeSlosh and

        That doesn't prove that white and black are populations or that they're independent lineages. Don't mistake outputs of PCA and Structure for real populations, they're not

        1 reply 0 retweets 1 like
      10. 22 more replies

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