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B_resnick's profile
Brian Resnick
Brian Resnick
Brian Resnick
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@B_resnick

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Brian ResnickVerified account

@B_resnick

Science reporter @voxdotcom: psychology, stars, nature, health, and “whoa that’s cool.” http://www.vox.com/authors/brian-resnick …

Washington, DC
brian-resnick.com
Joined May 2011

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    1. Brian Resnick‏Verified account @B_resnick Aug 23

      Hello! I have written an explainer on genome-wide association studies and genetic risk. https://www.vox.com/science-and-health/2018/8/23/17527708/genetics-genome-sequencing-gwas-polygenic-risk-score … Working on this story made me feel like my brain was going to explode.

      12 replies 96 retweets 180 likes
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    2. Brian Resnick‏Verified account @B_resnick Aug 23

      there's just so much to explore. So much cool basic science, some really cool promise for health, a boatload of caveats. And, generally, it’s really hard to write about risk while avoiding hype

      1 reply 0 retweets 5 likes
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    3. Brian Resnick‏Verified account @B_resnick Aug 23

      But I wanted to get it down. Because genetic science is not slowing down. These studies are growing bigger, their conclusions more bold.

      1 reply 0 retweets 4 likes
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    4. Brian Resnick‏Verified account @B_resnick Aug 23

      And people, via their genetic info they obtain via 23&me or some such, are going to encounter these findings long before this science is ready for the doctors office.

      1 reply 0 retweets 3 likes
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    5. Brian Resnick‏Verified account @B_resnick Aug 23

      I fear there's a lot to misunderstood here (especially as some of the studies are on creepy-sounding things, like the genetics of staying in school). And we have to make sure this genetic science doesn't get turned into "genetic astrology," or something darker

      2 replies 1 retweet 6 likes
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    6. Brian Resnick‏Verified account @B_resnick Aug 23

      At the very least, I was taken aback of the basic science here. Our genomes are wildly wildly complicated. They are the blueprints of our biology. But the blueprint is like this crazy MC Escher drawing.

      2 replies 3 retweets 3 likes
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    7. Brian Resnick‏Verified account @B_resnick Aug 23

      Single parts of the genome interact with so many others in mind-bendy ways. Some of this science may look like it's in the vein of "playing god," but really, we're staring into something extremely, but beautifully, hard to understand.

      1 reply 0 retweets 5 likes
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      Brian Resnick‏Verified account @B_resnick Aug 23

      Anyway. I want to keep writing on the topic of polygenic risk, how it could change medicine, how it could be misused, what's hype, and what's not. Send me ideas! brian@vox.com

      6:20 AM - 23 Aug 2018
      • 1 Retweet
      • 8 Likes
      • Dr Saskia Sanderson Simon Martin Dr. Jen Phillips Pam Davis-Kean, PhD Alicia Martin Jesse Hoff Saloni Dr. Kara Feilich James Pitt 🌹
      6 replies 1 retweet 8 likes
        1. Pam Davis-Kean, PhD‏ @pdakean Aug 23
          Replying to @B_resnick

          Excellent job! @ebwarephd and @colterm are experts in this area and spend a lot of time on the race issue and GWAS. It is a serious limitation. The lack of population representation is also a problem in generalizing this data. However, at least they are looking at actual genes

          0 replies 0 retweets 2 likes
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        1. Josiah Zayner‏ @4LOVofScience Aug 23
          Replying to @B_resnick

          If you haven't I would suggest talking to @Graham_coop and reading thishttps://gcbias.org/2018/03/14/polygenic-scores-and-tea-drinking/ …

          0 replies 0 retweets 2 likes
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        1. David Eccles (Māo/32)‏ @gringene_bio Aug 24
          Replying to @B_resnick

          I wrote a book on this a few years back: http://researcharchive.vuw.ac.nz/handle/10063/1987 …pic.twitter.com/pGCfHqgIfq

          0 replies 0 retweets 1 like
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        1. David Eccles (Māo/32)‏ @gringene_bio Aug 24
          Replying to @B_resnick

          David Eccles (Māo/32) Retweeted David Eccles (Māo/32)

          A bigger problem with population structure is that GWAS results may not even be relevant in the population that is being studied, let alone other populations. It's too easy to identify the wrong variants because case/control have different ancestries.https://twitter.com/gringene_bio/status/1021600178329935873 …

          David Eccles (Māo/32) added,

          David Eccles (Māo/32) @gringene_bio
          Replying to @gringene_bio @NickJMatzke and 2 others
          The study was done on europeans and validated in europeans, but a GWAS emphasises differences; any subtle difference in population structure between cases and controls will be pulled out in stark relief.
          0 replies 0 retweets 0 likes
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        1. Dr. Erin B. Ware‏ @ebwarephd Aug 24
          Replying to @B_resnick

          Hey Brian! Checkout https://www.biorxiv.org/content/early/2017/02/05/106062 … we’re hoping to have it out in peer-review this year!

          0 replies 0 retweets 0 likes
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        1. Kas Thomas‏ @kasthomas Aug 23
          Replying to @B_resnick

          http://asserttrue.blogspot.com/2015/01/the-problem-of-missing-heritability.html … http://asserttrue.blogspot.com/2015/01/where-are-alcoholism-genes.html … http://asserttrue.blogspot.com/2015/01/where-are-schizophrenia-genes.html …

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