there's just so much to explore. So much cool basic science, some really cool promise for health, a boatload of caveats. And, generally, it’s really hard to write about risk while avoiding hype
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But I wanted to get it down. Because genetic science is not slowing down. These studies are growing bigger, their conclusions more bold.
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And people, via their genetic info they obtain via 23&me or some such, are going to encounter these findings long before this science is ready for the doctors office.
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I fear there's a lot to misunderstood here (especially as some of the studies are on creepy-sounding things, like the genetics of staying in school). And we have to make sure this genetic science doesn't get turned into "genetic astrology," or something darker
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At the very least, I was taken aback of the basic science here. Our genomes are wildly wildly complicated. They are the blueprints of our biology. But the blueprint is like this crazy MC Escher drawing.
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Single parts of the genome interact with so many others in mind-bendy ways. Some of this science may look like it's in the vein of "playing god," but really, we're staring into something extremely, but beautifully, hard to understand.
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Anyway. I want to keep writing on the topic of polygenic risk, how it could change medicine, how it could be misused, what's hype, and what's not. Send me ideas! brian@vox.com
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Very well written, an excellent overview!
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Hello Back Brian. Giving a Second RT Which Your Fine Explanatory Piece Is Most-Deserving Of. Thanks for a Great Genetics Lesson and Regards to You Sir.
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Please point to one of Zimmer’s “538 genes with clear-cut influence on intelligence test scores” that is causally established as such. Besides IQ tests are not tests of intelligence in any general sense. This is how myths are created.
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EdYrs reflects social background and genetic heritage (i.e. poorly controlled population stratification) so scope for spurious correlations is enormous. This is suggested in the PNAS triple graph (even with crude measures - check Methods). EdYrs poorly predicts job performance.
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Enlightened. Pity about the myths left hanging. Genes are not blueprints, but utterly inert templates; i.e. resources not causes. The intentional genome with “thumb on the scales”, “deciding” weeks in education, or “raising IQ 0.001 percent”, is pure superstition.
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"The effect of each SNP is tiny" wheres the proof they actually have an effect?
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Very interesting and clear, thanks!
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Will read. I hope you applied the Ioannidis lens to GWAS
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This was an excellent piece. Congratulations!
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any way to turn off the flashing banner at the top? https://en.wikipedia.org/wiki/Photosensitive_epilepsy …
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have you tried an ad blocker?
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"Intelligence is highly heritable" is something I'm happy to read in Vox. But your warnings section about abuse is very one-sided. It would similarly be nonsense for car insurance to charge higher premiums based on the presence of a Y chromosome. But at group level it works.
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