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B_resnick's profile
Brian Resnick
Brian Resnick
Brian Resnick
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@B_resnick

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Brian ResnickVerified account

@B_resnick

Science reporter @voxdotcom: psychology, stars, nature, health, and “whoa that’s cool.” http://www.vox.com/authors/brian-resnick …

Washington, DC
brian-resnick.com
Joined May 2011

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    Brian Resnick‏Verified account @B_resnick Aug 23

    Hello! I have written an explainer on genome-wide association studies and genetic risk. https://www.vox.com/science-and-health/2018/8/23/17527708/genetics-genome-sequencing-gwas-polygenic-risk-score … Working on this story made me feel like my brain was going to explode.

    6:13 AM - 23 Aug 2018
    • 96 Retweets
    • 180 Likes
    • CoriolanusSnow 🌹 Simone Herrera Sandy Irvin Sarah Banks PhD Christian Jarrett SPOK Karsten Borgwardt Topher Hübel Farah
    12 replies 96 retweets 180 likes
      1. New conversation
      2. Brian Resnick‏Verified account @B_resnick Aug 23

        there's just so much to explore. So much cool basic science, some really cool promise for health, a boatload of caveats. And, generally, it’s really hard to write about risk while avoiding hype

        1 reply 0 retweets 5 likes
        Show this thread
      3. Brian Resnick‏Verified account @B_resnick Aug 23

        But I wanted to get it down. Because genetic science is not slowing down. These studies are growing bigger, their conclusions more bold.

        1 reply 0 retweets 4 likes
        Show this thread
      4. Brian Resnick‏Verified account @B_resnick Aug 23

        And people, via their genetic info they obtain via 23&me or some such, are going to encounter these findings long before this science is ready for the doctors office.

        1 reply 0 retweets 3 likes
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      5. Brian Resnick‏Verified account @B_resnick Aug 23

        I fear there's a lot to misunderstood here (especially as some of the studies are on creepy-sounding things, like the genetics of staying in school). And we have to make sure this genetic science doesn't get turned into "genetic astrology," or something darker

        2 replies 1 retweet 6 likes
        Show this thread
      6. Brian Resnick‏Verified account @B_resnick Aug 23

        At the very least, I was taken aback of the basic science here. Our genomes are wildly wildly complicated. They are the blueprints of our biology. But the blueprint is like this crazy MC Escher drawing.

        2 replies 3 retweets 3 likes
        Show this thread
      7. Brian Resnick‏Verified account @B_resnick Aug 23

        Single parts of the genome interact with so many others in mind-bendy ways. Some of this science may look like it's in the vein of "playing god," but really, we're staring into something extremely, but beautifully, hard to understand.

        1 reply 0 retweets 5 likes
        Show this thread
      8. Brian Resnick‏Verified account @B_resnick Aug 23

        Anyway. I want to keep writing on the topic of polygenic risk, how it could change medicine, how it could be misused, what's hype, and what's not. Send me ideas! brian@vox.com

        6 replies 1 retweet 8 likes
        Show this thread
      9. End of conversation
      1. Karsten Borgwardt‏ @kmborgwardt Aug 27
        Replying to @B_resnick @ksuhre

        Very well written, an excellent overview!

        0 replies 0 retweets 1 like
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      1. Yoni Maisel.‏ @Primary_Immune Aug 23
        Replying to @B_resnick

        Hello Back Brian. Giving a Second RT Which Your Fine Explanatory Piece Is Most-Deserving Of. Thanks for a Great Genetics Lesson and Regards to You Sir.

        0 replies 0 retweets 1 like
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      1. Ken Richardson‏ @kenrich12 Aug 26
        Replying to @B_resnick

        Please point to one of Zimmer’s “538 genes with clear-cut influence on intelligence test scores” that is causally established as such. Besides IQ tests are not tests of intelligence in any general sense. This is how myths are created.

        0 replies 0 retweets 0 likes
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      1. Ken Richardson‏ @kenrich12 Aug 26
        Replying to @B_resnick

        EdYrs reflects social background and genetic heritage (i.e. poorly controlled population stratification) so scope for spurious correlations is enormous. This is suggested in the PNAS triple graph (even with crude measures - check Methods). EdYrs poorly predicts job performance.

        0 replies 0 retweets 0 likes
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      1. Ken Richardson‏ @kenrich12 Aug 26
        Replying to @B_resnick

        Enlightened. Pity about the myths left hanging. Genes are not blueprints, but utterly inert templates; i.e. resources not causes. The intentional genome with “thumb on the scales”, “deciding” weeks in education, or “raising IQ 0.001 percent”, is pure superstition.

        0 replies 0 retweets 0 likes
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      1. Picolo Martin‏ @EnderRaptor Aug 25
        Replying to @B_resnick

        "The effect of each SNP is tiny" wheres the proof they actually have an effect?

        0 replies 0 retweets 0 likes
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      1. Yochai‏ @Edlitz Aug 24
        Replying to @B_resnick @ewanbirney

        Very interesting and clear, thanks!

        0 replies 0 retweets 0 likes
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      1. Raphi Sirt‏ @raphaels7 Aug 24
        Replying to @B_resnick @AdamRutherford

        Will read. I hope you applied the Ioannidis lens to GWAS

        0 replies 0 retweets 0 likes
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      1. Navin Pokala‏ @NavinPokala Aug 23
        Replying to @B_resnick

        This was an excellent piece. Congratulations!

        0 replies 0 retweets 0 likes
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      1. New conversation
      2. Leonid Kruglyak‏ @leonidkruglyak Aug 23
        Replying to @B_resnick

        any way to turn off the flashing banner at the top? https://en.wikipedia.org/wiki/Photosensitive_epilepsy …

        1 reply 0 retweets 0 likes
      3. this can be anything‏ @webramblin Aug 24
        Replying to @leonidkruglyak @B_resnick

        have you tried an ad blocker?

        0 replies 0 retweets 0 likes
      4. End of conversation
      1. Toxic 🚫Centrism‏ @ExcludedMuddle Aug 23
        Replying to @B_resnick

        "Intelligence is highly heritable" is something I'm happy to read in Vox. But your warnings section about abuse is very one-sided. It would similarly be nonsense for car insurance to charge higher premiums based on the presence of a Y chromosome. But at group level it works.

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