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    Bence Ölveczky‏ @BOlveczky 5. stu 2019.
    • Prijavi Tweet

    (Thread) Proud to present two recent papers from the lab on how the basal ganglia contribute to motor skills. All credit goes to remarkable PDs, Ashesh Dhawale and @SBE_Wolff . This is our first attempt at a tweeprint or whatever this is.... it's long… but hang in there..1/n

    10:58 - 5. stu 2019.
    • 55 proslijeđenih tweetova
    • 158 oznaka „sviđa mi se”
    • Mohsen Omrani Justin Mark Stewart Rebekah Evans Aminda O'Hare Giacomo Ariani Juan Álvaro Gallego Timothy Verstynen Shaghayegh Aryana Yousefzadeh Dr. John Hernandez
    55 proslijeđenih tweetova 158 korisnika označava da im se sviđa
      1. Novi razgovor
      2. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        This work started a few years ago. We were training rats on precisely timed lever press sequences and found that they responded, after weeks of training, with beautifully choreographed little dances. 2/n

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      3. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        These were particular to each animal and very stereotyped. Once learned, they were stable over months. Here are four trials each from two of our amazing rats, Jane and Maine. 3/npic.twitter.com/nWkH5fLhXE

        1 reply 6 proslijeđenih tweetova 16 korisnika označava da im se sviđa
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      4. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        These behaviors have some intriguing qualities that reminded us of similar over trained behaviors in humans. Here is a spectacular example of bread makers in Ashesh’s home country of India. 4/npic.twitter.com/My1rrFUeUf

        1 reply 1 proslijeđeni tweet 17 korisnika označava da im se sviđa
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      5. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        But how do our rats produce the skilled behaviors acquired in our task? A few years ago we found, to our surprise, that motor cortex (MC) is not required. The paper on that story is here. 5/nhttps://www.sciencedirect.com/science/article/pii/S0896627315002202 …

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
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      6. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        But if not the MC, which circuits are responsible? In the first of our two preprints, we describe the role of the basal ganglia (BG) in the execution of these stereotyped behaviors. 6/nhttps://www.biorxiv.org/content/10.1101/827261v1 …

        1 reply 3 proslijeđena tweeta 4 korisnika označavaju da im se sviđa
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      7. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Based on the literature, we suspected that the BG will be involved in initiating the skilled behaviors and/or modulating their ‘vigor’ (i.e. speed/amplitude), with detailed kinematic structure being controlled from downstream circuits in brainstem-midbrain-cerebellum. 7/n

        1 reply 0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
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      8. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        The first clue that BG may have a larger role to play came from Ashesh’s recordings in the striatum - the input nucleus of the BG. But before we look at the recordings, let’s remind ourselves of how the BG are connected to the rest of the motor system. 8/n

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      9. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        The BG form loops with cortex, thalamus, and brainstem. These are topographically organized, with the dorsolateral striatum (DLS) receiving input from sensorimotor cortex, and projecting to control regions of the brain. 9/npic.twitter.com/sxtEdMSbHX

        1 reply 1 proslijeđeni tweet 8 korisnika označava da im se sviđa
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      10. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Dorsomedial striatum (DMS), on the other hand, is part of the associative ‘loop’, and receives most of its input from PFC and PPC. We recorded activity from both sub-regions of the striatum in expert rats with well developed ‘dances’. 10/n

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      11. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Here is a video showing our neural and behavioral recordings, and the spiking activity of two (red and blue) spiny projection neuron (SPNs) in the DLS of Hindol, another favorite rat. 11/npic.twitter.com/1jvltnvQ69

        1 reply 2 proslijeđena tweeta 7 korisnika označava da im se sviđa
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      12. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Now compare the activity of neurons in DLS and DMS. See the difference? The DLS representation is continuous and each SPN is locked to a particular phase of the behavior. DMS neurons are much less modulated. Also no prominent start/stop activity. 12/npic.twitter.com/NJ9OyqE6B4

        1 reply 0 proslijeđenih tweetova 11 korisnika označava da im se sviđa
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      13. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        DLS activity allowed us to decode the details of the rats' behaviors, DMS activity did not. Shown are observed and decoded aspects of kinematics and timing of the motor sequences. 13/npic.twitter.com/FqqtrAkfAD

        1 reply 0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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      14. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        OK, but remember that MC is NOT important for executing the learned behavior. Remember also that MC provides a major input to the DLS. If activity in the DLS reflects a role in control, then the representation should NOT depend on input from the MC. 14/n

        1 reply 0 proslijeđenih tweetova 2 korisnika označavaju da im se sviđa
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      15. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Ashesh and Steffen looked at this. And voila: the nature of the representation in DLS did not change after removing the MC. Ashesh could decode the behavior just as well without MC input to the DLS.15/npic.twitter.com/kLTXJoAufJ

        1 reply 0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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      16. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Interesting. So what role do the motor cortical inputs to DLS play? That is something we'll revisit in the second paper, so stay tuned. Now back to the DLS. Its activity tells us about the behavior, but correlation is not causation, you say, and we agree. 16/n

        1 reply 0 proslijeđenih tweetova 2 korisnika označavaju da im se sviđa
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      17. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        To look at whether DLS activity reflects a causal contribution to the learned behaviors, Steffen and Raymond Ko (a student of mine) decided to lesion it in expert animals. They also lesioned DMS as a control (units in DMS are not correlated with behavior). 17/n

        1 reply 0 proslijeđenih tweetova 2 korisnika označavaju da im se sviđa
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      18. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        DMS rats had no problem reproducing their ‘dances’, but DLS lesioned animals showed no signs of their learned behavior. They were pressing the lever after the lesions, but in ways that were strikingly similar to their initial attempts at start of training (each shade a rat).18/npic.twitter.com/7tZ6Xd4goL

        1 proslijeđeni tweet 8 korisnika označava da im se sviđa
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      19. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Indeed, our DLS lesioned rats all reverted back to a simple lever-pressing behavior that was similar across rats. We speculate that our rats press levers by adapting a species-typical behavior generated by 'hardwired' circuits in the brainstem/midbrain. 19/n

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      20. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        This may be the default way for a rat to press a lever - all our rats start out this way. But, they can earn a higher rate of reward in our task if they change their movements, insert new elements etc. And that's indeed what they do, hence the ‘dances’. 20/n

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      21. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        We believe the demand for new task-specific behaviors recruits the BG, which modify the innate pressing behavior. 21/n

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      22. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        OK. That’s interesting (we think). But how do the BG learn to do what they do? And how can these circuits perform their control function without input from the MC? 22/n

        1 reply 0 proslijeđenih tweetova 3 korisnika označavaju da im se sviđa
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      23. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        These questions were the starting point for our second study, now also published in preprint form. 23/nhttps://www.biorxiv.org/content/10.1101/825810v1 …

        1 reply 0 proslijeđenih tweetova 9 korisnika označava da im se sviđa
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      24. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Consider again the BG related neural circuits. DLS receives excitatory input from both thalamus and MC. We had previously shown that MC is required for learning the skills we train, but not for their executing them once acquired. 24/n

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      25. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        We wondered whether this ‘tutor’ function of the MC is mediated through its projections to the striatum (i.e. DLS)? To find out, Steffen silenced neurons in MC that project to the DLS before he introduced the animals to our task. 25/n

        1 reply 0 proslijeđenih tweetova 4 korisnika označavaju da im se sviđa
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      26. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        The results were unequivocal. Rats did NOT learn the task, no ‘dances’ emerged from the training. When Steffen silenced DLS-projecting MC neurons after learning, he saw no effect. We take this to mean that MC ‘tutors’ subcortical circuits through its projection to the DLS. 26/n

        0 proslijeđenih tweetova 6 korisnika označava da im se sviđa
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      27. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Let’s return to the question of how these ‘dances’ are generated. Remember that the DLS, which is an essential cog here, also receives input from the thalamus. If you didn’t know this, it may be because this connection is often omitted from textbook chapters on the BG.

        1 reply 0 proslijeđenih tweetova 7 korisnika označava da im se sviđa
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      28. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        However, thalamic inputs to the DLS are comparable in strength and numbers to those from cortex. Steffen probed their function through the lens of the idiosyncratic behaviors we train. 27/n

        1 reply 0 proslijeđenih tweetova 5 korisnika označava da im se sviđa
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      29. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        He silenced neurons in thalamus that project to the DLS in expert animals with well developed ‘dances’. Upon silencing, no more dancing. Animals reverted back to the species-typical lever pressing behaviors we see early in training and after DLS lesions. 28/n

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
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      30. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Steffen further showed that plasticity at excitatory synapses in DLS is essential for ‘storing’ the learned behaviors. Given that MC input to the striatum is dispensable, this suggests that plasticity happens at one of the other inputs to DLS, perhaps the thalamic ones. 29/n

        1 reply 0 proslijeđenih tweetova 8 korisnika označava da im se sviđa
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      31. Bence Ölveczky‏ @BOlveczky 5. stu 2019.
        • Prijavi Tweet

        Much is left to figure out about how these behaviors are learned and controlled, but I hope these studies will bring us a step closer to understanding how the mammalian brain learns new motor skills. Thanks for reading to the end!

        1 reply 0 proslijeđenih tweetova 26 korisnika označava da im se sviđa
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