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Alex Telford proslijedio/la je Tweet
Novartis' summary slide on Zolgensma launch — treated 100 patients just in Q4?pic.twitter.com/AowGMsVRFB
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Alex Telford proslijedio/la je Tweet
Best list yet of all the genome editing trials in humans (n=37) so far. https://twitter.com/Primary_Immune/status/1217467118427439105 …pic.twitter.com/AVYIe1viy6
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Alex Telford proslijedio/la je Tweet
This is probably the most interesting stat in 2020 E&Y Firepower Report and explains the lack of M&A at
#JPM20 "69% of surveyed dealmakers say the valuation gap between buyers and sellers is the largest its been since 2008" https://assets.ey.com/content/dam/ey-sites/ey-com/en_gl/topics/life-sciences/life-sciences-pdfs/ey-firepower-report-2020-how-will-deals-done-now-deliver-what-the-health-ecosystem-needs-next.pdf …pic.twitter.com/S2wypdgzG4
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Alex Telford proslijedio/la je Tweet
I missed this paper, "A Structured Approach to Strategic Decisions," by Danny Kahneman, @dan_lavallo and
@SibOliv in@mitsmr. Good stuff: http://ilp.mit.edu/media/news_articles/smr/2019/60314.pdf …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Alex Telford proslijedio/la je Tweet
Target Protein Degradation commanding a lot of attention https://bit.ly/2QCbLhw :
#Nurix collab w/$SNY: $55M u/f , $2.5B in biobucks after, 5 targets, DELs + E3 proteins. Options to co-dev/co-promote. Nice summary by@WilliamBlair on previous deals in the space:pic.twitter.com/QGfgcgPF0F
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Alex Telford proslijedio/la je Tweet
The scientific foundation for our milasen work was Spinraza, birthed by Adrian Krainer & Frank Bennett. Just 1 of the reasons I’m grateful to
@DrStanleyCrooke@ionispharma &@biogen for this launch, supporting more individualized txs for ultrarare disease.http://bit.ly/cennloremHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Alex Telford proslijedio/la je Tweet
Monday's Wall Street Journal story on the need to reform how we pay for antibiotics. https://www.wsj.com/articles/antibiotic-makers-find-rewards-for-tackling-superbugs-are-scarce-11578259557?shareToken=st4160a3e14ca1447bbdf2e4541878779f&reflink=article_email_share …pic.twitter.com/Mkemc73QPV
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Alex Telford proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Alex Telford proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Alex Telford proslijedio/la je Tweet
Some complain that the FDA is too hard on the pharmaceutical industry. It's hard for me to
too much for them. Consider these trends over time:
1- user fees
2- warning letters
3- % of drug applications approved
https://twitter.com/agamemnus_dev/status/1211447830444941312 …pic.twitter.com/jblsHDeKkb
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Alex Telford proslijedio/la je Tweet
How we know what not to think The total number of possibilities is too large. Authors propose we have a cache of unconscious preferences coded to be of higher value or probability which are then actively selected from.https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(19)30231-1 …
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Alex Telford proslijedio/la je Tweet
2019 will be remembered for the 1st hyper-personalized, true N of 1, from sequence to therapy in < 1 year https://www.nature.com/articles/s41591-019-0700-3.pdf …
@NatureMedicine https://worldin.economist.com/article/17520/edition2020creating-personalised-drugs?navigation=true&category=extra …@TheEconomist@natashaloder https://www.nejm.org/doi/pdf/10.1056/NEJMoa1813279?articleTools=true …@NEJM@timyu@BostonChildrens https://www.statnews.com/2018/10/22/a-tailor-made-therapy-may-have-halted-a-rare-disease/ …pic.twitter.com/wTNq22LQfH
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Alex Telford proslijedio/la je Tweet
Updated analysis of recent biotech IPOs that were taken out. Premiums are 118% higher in 19' compared to next highest year. As mentioned,big pharma will need to acquire growth given patent cliffs & outsourcing of early R&D to smaller Cos. $91B of M&A has gone to recent IPOs
$BOLDpic.twitter.com/7t5j14Xaio
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Alex Telford proslijedio/la je Tweet
Interesting point: "As a simple rule of thumb...about 50% of the accuracy improvements...going from the regulars to the super[forecaster]s can be attributed to noise reduction. The remaining 25% is information improvement...and...25% [is] bias reduction."https://knowledge.wharton.upenn.edu/article/want-better-forecasting-silence-the-noise/ …
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Alex Telford proslijedio/la je Tweet
$CRSP$VRTX Very encouraging early data for#CRISPR/Cas9 ex vivo HSCT therapy http://www.globenewswire.com/news-release/2019/11/19/1949325/0/en/CRISPR-Therapeutics-and-Vertex-Announce-Positive-Safety-and-Efficacy-Data-From-First-Two-Patients-Treated-With-Investigational-CRISPR-Cas9-Gene-Editing-Therapy-CTX001-for-Severe-He.html … But the tough safety profile highlights why we need better non-chemo conditioning regimen, thus why we saw$VRTX +$MTEM,$BLUE +$FTSV deal in the past several days.pic.twitter.com/Ok6spq0Zlc
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Alex Telford proslijedio/la je Tweet
NEW RESEARCH provides safety, efficacy, and tolerability data for adjunctive cenobamate for patients with uncontrolled focal seizures. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(19)30399-0/fulltext … Expert commentary from Stephan Arnold suggests that cenobamate could offer new hope for treatment-resistant epilepsypic.twitter.com/E80cWVwFCY
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Alex Telford proslijedio/la je Tweet
**GIVEAWAY** The new TV adaption of
#HisDarkMaterials starts tonight on the@BBC! To celebrate, we’re giving you a chance to win a copy of our set of His Dark Materials SIGNED by Philip Pullman and Peter Bailey. RT to enter. Competition ends on 5 November. Best of luck!pic.twitter.com/icOsFXjuBl
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Alex Telford proslijedio/la je Tweet
Okay, here are my prime editing takes. I'm mostly going to try to be a voice of reason here. Not because I'm hyper critical of the paper but because it's necessary. This field is full of mega hype and cool tech, but cool doesn't get us anywhere unless it works as advertised.
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Alex Telford proslijedio/la je Tweet
The amazing Mila story of N-of-1 trial for saving a 6yo girl w
#Batten’s Disease using a personalized antisense oligonucleotide now in NEJM!@stopbatten https://www.nejm.org/doi/full/10.1056/NEJMoa1813279?query=featured_home … Editorial on Individualized Therapies by FDA's Janet Woodcock and Peter Marks https://www.nejm.org/doi/full/10.1056/NEJMe1911295?query=recirc_curatedRelated_article …pic.twitter.com/JyylEzVwEA
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Alex Telford proslijedio/la je Tweet
Here’s a great deck to help understand what makes Costco so unique. This is why is so unlikely that it may be disrupted anytime soon.https://www.dropbox.com/s/7hohqj3rl2uv43p/COSTCO%20Deck.pdf?dl=0 …
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