This started in ~November last year, but I couldn't do much until December because of work, and I did a complete rewrite of the post starting this year, so not sure how many hours of work went into this. There are probably still mistakes remaining
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But I hope it is useful. I'll take not of corrections and re-release it noting the changes made.
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Also to make
@david_perell happy, I've taken mental note of what I was thinking as I wrote it, so I'll do a followup post with the 'how it was made'Prikaži ovu nit -
I just added a table of contents to make it easier to navigate and know how it is structured
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Nice work. It seems like many of things that can help also have a 1/3 chance of significantly decreasing lifespan. Given treatment effects around 10-20% and likely attenuation from mice -> healthy humans, I guess we have a long way to go. :-(
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I'd be more optimistic than that! The decrease lifespan is if you overdo the dose
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Re: animal models Hear the Eric-
@BretWeinstein podcast? Claims: 1. Lab mice in US come from two labs 2. Breeding mice killed after ~8 months because useless => no selection pressure from cancer => lab mice have super long telomeres => corrupted sciencehttps://www.stitcher.com/podcast/kast-media-2/the-portal-2 … -
Many, but not all; and there are many strains. But there are other issues, mice are inbred and not genetically diverse within a strain, and lab conditions are too clean, plus they get obese etc. The ITP trials I mention do account for this with more heterogenenous mice
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Amazing, it's like a small book on the subject! Hoping I find the time to dive in sometime soon

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Hah just 23 pages in A4 of supercompressed info
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Čini se da učitavanje traje već neko vrijeme.
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