Anne Feng

@AnnejaneF

genetic epi by training, intrigued by all things statistical/human genetics. postoc at MGH and Broad Institute.

Vrijeme pridruživanja: travanj 2011.

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  1. proslijedio/la je Tweet
    28. sij

    A really daft paragraph. Imagine society discriminates against (say) short people. Then as height has a genetic basis, so will discrimination, and so discrimination will built into PGS of traits affected by discrimination.

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  2. proslijedio/la je Tweet
    28. sij

    This is how we married LD score regression & MR to learn about genetic architecture and causality at the same time via harnessing information on all markers genome-wide.

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  3. proslijedio/la je Tweet
    27. sij

    In 2015, Nelson et al estimate that drug targets with support from GWAS studies are twice as likely to succeed: Now, King et al show this estimate to be even higher:

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  4. proslijedio/la je Tweet
    17. sij

    I want to give more specifics about my main concerns with this pre-print on polygenic scores (PGS) in carriers of rare high-risk variants (e.g. pathogenic mutations in BRCA1). /THREAD

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  5. proslijedio/la je Tweet
    8. sij

    Our review of recent past & near future of human disease genetics (1990-2030) has just been published in Nature (). Thanks to co-authors too numerous to list, & to et al at Nature (including the reviewers) for pulling this together. 1/n

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  6. proslijedio/la je Tweet
    14. sij

    Really happy to start to make FinnGen results more broadly available!

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  7. proslijedio/la je Tweet
    13. sij

    Delighted to see our work on de novo mutations in schizophrenia out today in + our results integrated into the paper by et al. below. Open science for the win! Special thanks to the contributing families in Taiwan, whose genetic data made this work possible

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  8. 12. pro 2019.

    So happy this is finally out! a massively collaborative effort led by Phil Lee and 🙏 We have (of course!) released the summary statistics here:

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  9. proslijedio/la je Tweet
    30. stu 2019.

    After being told of BRCA1 mutation, up to 50% women opt for prophylactic mastectomy Should this be so? For "monogenic" forms breast ca, colorectal ca, & heart attack, we find polygenic background powerfully modifies risk New on

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  10. proslijedio/la je Tweet
    18. lis 2019.

    HM: will focus on epilepsy (DEE), 40 drugs available but most don't work, novel therapies needed. ~25-50% of NDD cases can be diagnosed via WES and CNV.

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  11. proslijedio/la je Tweet
    15. lis 2019.

    Our genetic correlation browser for UK Biobank phenotypes is up! - check out for an overview.

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  12. proslijedio/la je Tweet
    16. lis 2019.

    We’re excited to release fine-mapping results of 94 complex diseases and traits! This work is a joint effort of: , , Hilary Finucane, , and many other colleagues. 1/n and (soon)

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  13. proslijedio/la je Tweet
    1. lis 2019.

    Insulting people who are doing the right thing and correcting or retracting a paper is a really bad look. We need to be accepting of errors, and be kind to our colleagues, to make it easier to admit when things have gone wrong.

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  14. proslijedio/la je Tweet
    2. lis 2019.

    After digging into the apparent deviation from Hardy-Weinberg Equilibrium at CCR5-delta32, we identified an error mode in the gnomAD dataset relating to undercalling of homozygotes.

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  15. proslijedio/la je Tweet
    4. lis 2019.

    Our analysis of the relationship between CCR5-delta32 homozygosity and mortality in a sample of 37,650 subjects from three U.S.-based cohorts is just up on medRxiv. /thread

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  16. 4. lis 2019.

    No statistical evidence for an effect of CCR5-Δ32 on lifespan in the UK Biobank cohort

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  17. proslijedio/la je Tweet
    17. ruj 2019.

    Our new blog post is up on the Neale Lab site! We recently learned there are a lot of HWE-failing genotyped SNPs in UK Biobank, which might be of particular concern for downstream analysis such as fine-mapping.

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  18. proslijedio/la je Tweet
    4. ruj 2019.

    I love tea. I love genetics. But we're a long way from using polygenic scores to understand differences among groups in tea drinking & other behaviours. [Preprint version]

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  19. 29. kol 2019.

    Many Genes Influence Same-Sex Sexuality, Not a Single ‘Gay Gene’

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  20. proslijedio/la je Tweet
    6. kol 2019.

    Landmark paper out today comparing genetic risk scores and current clinical scores for identifying individuals at risk for common diseases using biobank data with *forty-six* years of follow-up on 135k Finns! 😳😮Congrats, 👏

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