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Anne Feng proslijedio/la je Tweet
A really daft paragraph. Imagine society discriminates against (say) short people. Then as height has a genetic basis, so will discrimination, and so discrimination will built into PGS of traits affected by discrimination.https://twitter.com/aaron__stern/status/1222266000889876480 …
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Anne Feng proslijedio/la je Tweet
This is how we married LD score regression & MR to learn about genetic architecture and causality at the same time via harnessing information on all markers genome-wide.https://www.medrxiv.org/content/10.1101/2020.01.27.20018929v1 …
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Anne Feng proslijedio/la je Tweet
In 2015, Nelson et al estimate that drug targets with support from GWAS studies are twice as likely to succeed: https://www.nature.com/articles/ng.3314 … Now, King et al show this estimate to be even higher: https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1008489 …pic.twitter.com/n85A0x8zp5
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Anne Feng proslijedio/la je Tweet
I want to give more specifics about my main concerns with this pre-print on polygenic scores (PGS) in carriers of rare high-risk variants (e.g. pathogenic mutations in BRCA1). /THREADhttps://twitter.com/EricTopol/status/1207745913466179584 …
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Anne Feng proslijedio/la je Tweet
Our review of recent past & near future of human disease genetics (1990-2030) has just been published in Nature (https://www.nature.com/articles/s41586-019-1879-7 …). Thanks to co-authors too numerous to list, & to
@obahcall et al at Nature (including the reviewers) for pulling this together.#humgen25 1/nPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Anne Feng proslijedio/la je Tweet
Really happy to start to make FinnGen results more broadly available!https://twitter.com/FinnGen_FI/status/1217053947418071040 …
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Anne Feng proslijedio/la je Tweet
Delighted to see our work on de novo mutations in schizophrenia out today in
@NatureNeuro + our results integrated into the paper by@ERees85 et al. below. Open science for the win! Special thanks to the contributing families in Taiwan, whose genetic data made this work possible https://twitter.com/ERees85/status/1216798537800994821 …pic.twitter.com/p34gCpq0mp
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So happy this is finally out! a massively collaborative effort led by Phil Lee and
@jorsmo
We have (of course!) released the summary statistics here: https://www.med.unc.edu/pgc/results-and-downloads/cd/ …https://twitter.com/jorsmo/status/1205175803605966848 …
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Anne Feng proslijedio/la je Tweet
After being told of BRCA1 mutation, up to 50% women opt for prophylactic mastectomy Should this be so? For "monogenic" forms breast ca, colorectal ca, & heart attack, we find polygenic background powerfully modifies risk New on
@medrxivpreprint https://www.medrxiv.org/content/medrxiv/early/2019/11/29/19013086.full.pdf …pic.twitter.com/zy7ITOJ8Q5
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Anne Feng proslijedio/la je Tweet
HM: will focus on epilepsy (DEE), 40 drugs available but most don't work, novel therapies needed. ~25-50% of NDD cases can be diagnosed via WES and CNV.
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Anne Feng proslijedio/la je Tweet
#ASHG19 Our genetic correlation browser for UK Biobank phenotypes is up! http://ukbb-rg.hail.is - check out http://tinyurl.com/y2a7j6ur for an overview.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Anne Feng proslijedio/la je Tweet
We’re excited to release
@uk_biobank fine-mapping results of 94 complex diseases and traits! This work is a joint effort of:@julirsch,@PardisSabeti, Hilary Finucane,@ENCODE_NIH, and many other colleagues. 1/n https://www.finucanelab.org/data and https://www.encodeproject.org (soon)#ASHG19Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Anne Feng proslijedio/la je Tweet
Insulting people who are doing the right thing and correcting or retracting a paper is a really bad look. We need to be accepting of errors, and be kind to our colleagues, to make it easier to admit when things have gone wrong.
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Anne Feng proslijedio/la je Tweet
After digging into the apparent deviation from Hardy-Weinberg Equilibrium at CCR5-delta32, we identified an error mode in the gnomAD dataset relating to undercalling of homozygotes.https://www.biorxiv.org/content/10.1101/784157v1 …
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Anne Feng proslijedio/la je Tweet
Our analysis of the relationship between CCR5-delta32 homozygosity and mortality in a sample of 37,650 subjects from three U.S.-based cohorts is just up on medRxiv. /threadhttps://www.medrxiv.org/content/10.1101/19006619v1 …
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No statistical evidence for an effect of CCR5-Δ32 on lifespan in the UK Biobank cohorthttps://www.biorxiv.org/content/10.1101/787986v2 …
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Anne Feng proslijedio/la je Tweet
Our new blog post is up on the Neale Lab site! We recently learned there are a lot of HWE-failing genotyped SNPs in UK Biobank, which might be of particular concern for downstream analysis such as fine-mapping.http://www.nealelab.is/blog/2019/9/17/genotyped-snps-in-uk-biobank-failing-hardy-weinberg-equilibrium-test …
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Anne Feng proslijedio/la je Tweet
I love tea. I love genetics. But we're a long way from using polygenic scores to understand differences among groups in tea drinking & other behaviours. [Preprint version] https://arxiv.org/abs/1909.00892
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Many Genes Influence Same-Sex Sexuality, Not a Single ‘Gay Gene’https://nyti.ms/2ZmHedC
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Anne Feng proslijedio/la je Tweet
Landmark paper out today
@biorxivpreprint comparing genetic risk scores and current clinical scores for identifying individuals at risk for common diseases using biobank data with *forty-six* years of follow-up on 135k Finns!
Congrats, @FinnGen_FI
https://www.biorxiv.org/content/10.1101/727057v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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