Sewing-machine insertion of flexible electrodes via small holes. Good progress on channel count + insertion, building on @m8ta's work. Also nice chip+packaging. Hard stuff. Much depends on gliosis, but Chong Xie's results promising. Laser would indeed be preferable to drill. 1/4https://twitter.com/antonioregalado/status/1151335093354582016 …
...unless you want cellular resolution instead of measuring blood flow/oxygenation...
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Willing to consider other plausible mechanisms with citation. (e.g. photoacoustic imaging of activity dependent contrast agent with resolution enhanced via adaptive optics corrected by ultrasound-induced cavitation guidestars...). A TED talk is not a citation. What u got?
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if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here...