Sewing-machine insertion of flexible electrodes via small holes. Good progress on channel count + insertion, building on @m8ta's work. Also nice chip+packaging. Hard stuff. Much depends on gliosis, but Chong Xie's results promising. Laser would indeed be preferable to drill. 1/4https://twitter.com/antonioregalado/status/1151335093354582016 …
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2-photon and sensor genes are not the only options here...
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...unless you want cellular resolution instead of measuring blood flow/oxygenation...
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Agreed, CCDs are hot, power hungry photon capturing machines, very hard to miniaturize. Imaging, optical or otherwise, is for structure. Neural Dynamics can be captured in it's native electrical format via electrodes.
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if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here...