Variable prediction accuracy of polygenic scores within an ancestry group https://doi.org/10.7554/eLife.48376 … - a reminder that polygenic scores can be confounded by all kinds of things... from @molly_przew + colleaguespic.twitter.com/fHIX7JWFiW
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All good questions! On (1), I think the complexity of the genome and of the brain are intertwined and understanding that relationship may help ground neuroscience (but I'm probably biased...)
And on the others, I am optimistic of making real progress in neuroscience - it feels like an exciting time to me, like we're on the cusp of a new understanding...
????? Best guess 1) probably the same thing, 2) probably not, 3) not as long as the paradigm of normal/pathological stands in the way, 4) only if psychiatric phenotypes are consider group expressions enhancing group survival and demonstrations of the important role of diversity.
I'm more pessimistic- doubt whether clever change in modeling or growing technical virtuosity will ever be sufficient to decipher the absurd complexity of either brain or gene- much less the astoundingly large # of permutations in their interaction.
1) Yes 2) i hope so 3) Probably 4) I haven’t the foggiest, and you won’t get an answer on here. For more on 1 and 3 and 4 see my forthcoming The Idea of the Brain.
Duh. 1) Should be brain.
Hmm. If we conceptualize the brain as a bottom-up elaboration of informational models coded in the genome, then the answer to #1 is clear - we must first understand the genome before we can fully understand the brain as an elaboration of the genome.
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