The nucleus is an important specialized compartment in cells that protects DNApic.twitter.com/mDQqWFOwJ1
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In cancer cells, this compartment can break open exposing DNA to things that can damage it.pic.twitter.com/AsEfUXPVeW
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We study this to better understand how these events could contribute to cancer development.pic.twitter.com/TyfbFDXrfw
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When the nucleus breaks open, we can detect holes in the compartment by watching markers flow out of the nucleus and fill the rest of cell. https://www.biorxiv.org/content/biorxiv/early/2020/01/11/2020.01.10.902296/F1.large.jpg …
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A protein called BAF is important for quickly repairing these holes.https://www.biorxiv.org/content/10.1101/2020.01.10.902296v1.full …
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We learned BAF is crucial for efficient repair, and without it, or it's binding partners, repair takes a long time. https://www.biorxiv.org/content/biorxiv/early/2020/01/11/2020.01.10.902296/F4.large.jpg …
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Learning this is exciting because understanding how our cells repair themselves to protect DNA could lead to a better understanding of how cancer develops.
#CuresStartHerepic.twitter.com/NBH5qX9sdZPrikaži ovu nit -
Enormous gratitude goes to
#TeamHatchLab Dr. Emily Hatch,@AmandaLynGunn@ZychMolly@luciandipeso@DrMammel Heather and Emma. Big thanks as well to all friends and colleagues at@HutchBasicSci@FredHutch for their help and support.pic.twitter.com/8oov5F4GnEPrikaži ovu nit
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Interesting, congrats! How do you think these ruptures/repairs fit in with the "normal" loss of nuclear membrane during mitosis? It is interesting that these ruptures would expose DNA to damage, but not mitotic loss of nucleus. (hard to articulate thoughts in short tweet...ha)
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Congratulations Ali :)
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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