Alex Bisson

@Alex___Bisson

Archaeal cell biologist. Assistant Professor of Biology at Brandeis University. Carried on the shoulders of tiny things.

Cambridge, MA
Vrijeme pridruživanja: studeni 2009.

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  1. Prikvačeni tweet
    26. tra 2019.

    I am thrilled to announce I'm starting my lab this fall. The Bisson Lab will investigate the cellular organization and cytoskeleton dynamics in the astonishing archaeal world. Keep an eye out for open positions - and our website filled with cool movies like these

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  2. proslijedio/la je Tweet
    21. sij

    Nice overview of the diversity of motile systems throughout the Tree of Life. Many of which, sadly, do not involve .

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  3. proslijedio/la je Tweet
    17. sij

    Video of our proposed hypothetical model for eukaryogenesis—the “Entangle-Engulf-Endogenize (E3)” model

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  4. proslijedio/la je Tweet
    15. sij

    Here is the next iteration of the "cells to scale" poster, now featuring microtubules! Thanks to all who contributed (names listed at bottom of image). Want to learn more about these organisms? There's a Gordon Conference for that!

    , , i još njih 5
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  5. proslijedio/la je Tweet
    15. sij

    I want to end by reiterating that organelle biology in bacteria and archaea is an area that is ripe for exploration. You can read our recent review for a perspective on the importance of studying the cell biology of organelles in bacteria and archaea.

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  6. proslijedio/la je Tweet
    2. sij

    1.For science to work for everyone, scientific meetings need to be affordable. Otherwise we create a situation where we enhance inequalities & promote the already privileged. Case in point: I have noticed a worrying upward trend in the cost to attend a number of society meetings.

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  7. proslijedio/la je Tweet
    27. pro 2019.

    Let’s improve visibility and career opportunities for women in the field of cryo-electron microscopy! I started a network on Academondo (). If you want to join- just sign up and then ask to join the ‘Women in CryoEM’ network!

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  8. proslijedio/la je Tweet
    18. pro 2019.

    Excited for this story to be out! Made possible by excellent collaborations with lab Nicolas Biais lab and Ankur Dalia!

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  9. proslijedio/la je Tweet
    16. pro 2019.

    Postdoctoral position available in the Absalon Lab. Don't hesitate to DM me for more information

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  10. 5. pro 2019.

    Feel free to write us with your rants, suggestions, and any kind of questions! Preprints are awesome because of that and this would definitely make our story better for the peer-reviewed version! Finally, wanted to thank everyone in the Bisson, Pohlschroder, and Pfeiffer labs!

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  11. 5. pro 2019.

    8) And here is our cartoon model coupling cell-wall processing, phospholipid processing, and cell elongation. But too many questions are still up in the air. What is going on with the S-layer array during these shape transitions? Or what is the driven force behind cell growth?

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  12. 5. pro 2019.

    7) As these proteins don't play a role in cell division at all, we propose these enzymes "hijack" the cytokinetic ring to promote cell envelope remodeling at midcell. In layman's terms, these guys grow from the middle! To prove that, we GFP-tagged the S-layer protein itself:

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  13. 5. pro 2019.

    6) They even "follow" the cytokinetic ring during cell division:

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  14. 5. pro 2019.

    5) But how cells organize this processing in space and time? To answer that, we GFP-tagged these enzymes and to our surprise, they all localize to the division site - where the cytoskeletal FtsZ polymer assemble the cytokinetic ring!

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  15. 5. pro 2019.

    4) Farid went further and showed that without phospholipid modification, cells were unable to either process S-layer proteins and anchor them to the membrane. That means that attachment of surface proteins requires both substrate and activation of the membrane!

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  16. 5. pro 2019.

    3) In this work, Farid observed a genomic correlation between the genes encoding the sortase responsible to anchor the S-layer to the membrane and 2 enzymes predicted to process and modify phospholipids. Intriguingly, when he deleted these genes, cells were all rod-shaped!

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  17. 5. pro 2019.

    2) Did I talk about cell shape? Haloarchaea are talented in regards to assuming different shapes. They are capable of developing and switch back and forth between disks and rods. But how do S-layer and other envelope compartments rearrange to accommodate such fast transitions?

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  18. 5. pro 2019.

    1) Mecky has been studying archaeal surface protein biogenesis. For example, they did some great work on the S-layer anchoring mechanism to membrane phospholipids. This is really important for cell shape, as S-layer is the main archaeal cell wall component (yes, no PG here!)

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  19. 5. pro 2019.

    I'm so proud of this paper. It's my first correspondent author's work. It's my first paper with , who I met only recently and hit off so quickly! And it's scientifically delightful as it demonstrates how archaeal cells teach us new tricks. Here are the take-home msgs

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  20. proslijedio/la je Tweet
    4. pro 2019.

    Vikash is presenting a poster on augmin-mediated microtubule branching . Here is a cool video from his poster, visit his poster (B165 on Monday, December 9, 2019) to see more exciting stuff!

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  21. proslijedio/la je Tweet
    2. pro 2019.

    We updated the academic job market preprint! We took a deeper look at "interplay between metrics" and provided more clarity to the lack of alignment between applicant and search committee values.

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