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Alex Peluffo proslijedio/la je Tweet
We estimated the age of mutation for more than 45 million SNPs in the human genome: https://human.genome.dating Find the paper on
@PLOSBiology :https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000586 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Alex Peluffo proslijedio/la je Tweet
Comprendre les
#technologies émergentes + Maîtriser leurs usages et leurs#impacts => Pour construire une sagesse#collective#Colloque de lancement du cycle d’études TESaCo, soutenu par@ASMP_officiel à l’@InstitutFrancepic.twitter.com/23LKxz2IRj
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Alex Peluffo proslijedio/la je Tweet
Demain
#Gattaca ? Quels défis sociaux, économiques et politiques posent les avancées en#génomique ? Comment anticiper pour mieux maîtriser ?@Alex_Peluffo, project leader genetic data analyses chez@Pharnextpic.twitter.com/UwQPlFbV2P
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Alex Peluffo proslijedio/la je Tweet
The graph you've been waiting for... For all you burger and imitation burger aficionados https://www.scientificamerican.com/article/whats-inside-meat-vs-meatless-burgers/ …
@sciam, great#dataviz by@msjonesnyc (w/ many surprise ingredients)pic.twitter.com/SR82b6UhNv
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Alex Peluffo proslijedio/la je Tweet
Exercise (leisure time physical activity) and its intensity are associated with a lower incidence of many types of
#cancer, from 9 cohorts, > 750,000 people https://ascopubs.org/doi/pdf/10.1200/JCO.19.02407 …@ASCO#openaccess by@theNCI's Charles Matthews and colleaguespic.twitter.com/u91xolRuWO
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Alex Peluffo proslijedio/la je Tweet
Remise de l'ordre national
du mérite à Virginie Courtier par Pierre-Henri Gouyon !
Bravo à notre nouveau chevalier ! 
@Biol4Ever@IJMonod@INSB_CNRSpic.twitter.com/vahLeDHI88
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Alex Peluffo proslijedio/la je Tweet
5th & final publication from PhD detailing a new method in T-Coffee for huge MSA (>1.4M seq). Very special thanks to
@cnotred for his mentorship over the years and all the authors & reviewers. Validating the method would have been unfathomably arduous without@nextflowio.https://twitter.com/NatureBiotech/status/1201585212750213127 …
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Alex Peluffo proslijedio/la je Tweet
fastGWA is ~89 times faster and only requires ~5% of RAM compared to BOLT-LMM-Inf in a data set with n=456,422 and m=8,531,416, and even ~4 times faster than PLINK2. fastGWA summary statistics for >2000 traits from the UK Biobank are available at http://fastgwa.info .https://twitter.com/NatureGenet/status/1199013689405399040 …
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Alex Peluffo proslijedio/la je Tweet
Bravo à l’équipe de
@Pharnext qui participait au@CrossduFigaro ce matin !!#Telethon2019#JeCoursPourLeTelethon#crossdufigaro2019pic.twitter.com/AT6GEapa6m
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Alex Peluffo proslijedio/la je Tweet
What an amazing story on BCL11A (the target of the CRISPR Rx here) "Medicines that mimic protective human mutations" From GWAS discovery 2007 (thx
@gabecasis) to mechanism 2008 (thx@bloodgenes) to now 2 patients treated (thx@VertexPharma@CRISPRTX)pic.twitter.com/4wvfJWLUH3
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Alex Peluffo proslijedio/la je Tweet
Awesome paper: if a promoter sequence is replaced by a random 100 bp DNA sequence, E. coli can restore activity in 60% of the cases with only one single mutation. Random sequences rapidly evolve into de novo promotershttps://www.nature.com/articles/s41467-018-04026-w …
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Alex Peluffo proslijedio/la je Tweet
Online
@NatureRevGenet: Structural variation in the sequencing era https://go.nature.com/2NP87PX pic.twitter.com/v0V95lWoZg
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Alex Peluffo proslijedio/la je Tweet
And the award for best statistical method that leverages GWAS summary statistics to gain insights into the genetic basis of complex traits and diseases goes to:
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Alex Peluffo proslijedio/la je Tweet
So, paper below getting lot of press *Single* presenilin mutation carrier Disease onset later than expected, labelled resistant Claim: resistance due to homozygosity for a mutation in APOE My post-pub peer review: Is claim true? No way to know with n=1 Is claim new? I guesspic.twitter.com/66uncMfnha
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Alex Peluffo proslijedio/la je Tweet
A potential protective mutation for a very severe, familial (PSEN1) form of
#Alzheimers: the value of sequencing people of extreme phenotypes, resistant to penetrance@NatureMedicine https://www.nature.com/articles/s41591-019-0611-3 …@ytquiroz@MGHmapp@MassGeneralNews and colleaguespic.twitter.com/bwO5Zudllc
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Alex Peluffo proslijedio/la je Tweet
A third of verified gene KO with CRISPR still show residual protein expression owing to translation reinitiation or exon skipping. Several proteins are still functional. The authors call for a systematic analysis of protein levels after genome editinghttps://www.nature.com/articles/s41592-019-0614-5 …
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Alex Peluffo proslijedio/la je Tweet
Great discussion of a recent
@nature deep learning paper. Bottom line: deep learning only slightly outperforms classical models for prediction of AKI, clinical applicability still unclear@danilobzdok@lab_pearsonhttps://twitter.com/kdpsinghlab/status/1176324139596111872 …
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Alex Peluffo proslijedio/la je Tweet
@lumanoble@henriqueteoton2 Our latest preprint online ... C. elegans locomotion remains stable over >200 generations of evolution despite divergence in the genetic structure of the traits over time! Thread below
. Comments are more than welcome!https://www.biorxiv.org/content/10.1101/778282v1 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Alex Peluffo proslijedio/la je Tweet
more cool stuff from the teotonio lab!
@henriqueteoton2https://twitter.com/biorxiv_evobio/status/1176244341695766528 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Alex Peluffo proslijedio/la je Tweet
More evidence that RNAseq studies should be taken with a grain of salt.
#proteomicshttps://twitter.com/maralbasoler/status/1157197973635391488 …
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Project Leader Genetic Data