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This doesn't mean blithely destroying our support networks or ignoring the computational challenges of predicting the externalities of our actions. But if you want to default on what is natural rather than what spreads freedom for all when the two conflict, you're a reactionary.
Yudkowsky's example of the insects bred for altruism that ate their children instead is instructive and if it can be generalized it is also damning. Do you have a response ready to go if it does generalize? Or does the war against God become a kind of post-biological lysenkoism?
I don't know what you mean by "generalize" here. It seems absurd to claim that there will be maximally counter-productive unforseen externalities in literally every instance of introducing a change or an effect.
If your goal is perfect liberty then any unforseen externalities are unacceptable. There is no stopping point. At what time do you start assessing trade offs if your commitment is literally infinite?
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