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So besides minor nitpicking that I probably couldn't defend half as well as Yudkowsky could counter, the only obvious problem I see so far is that he doesn't have a very complete picture of irrationality, its origins, developments, and functions. But I am only 400 pages in.
specifically he doesn't see how irrationality and rationality are at least partially symbiotic in a group context, how this probably evolved from pure exploitation, how interbreeding between exploiters and irrationals muddied the waters, and so forth. I tweet but may need to blog
Yud says "You're taking a blind leap when you practice instrumental irrationality" but doesn't see how thousands of years of evolution constrain the potential for maladaptive irrational behaviors in the same way they constrain rational behaviors.
Some (by no means all) irrationality is also just encrypted rationality
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