Excited to share that LINE-1-encoded ORF1p, our "hallmark of cancer" is detectable in the peripheral blood. 🩸 A brilliant collaboration with the Walt lab and many generous colleagues .
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Anirban Maitra
@Aiims1742
Pancreatic cancer researcher and GI pathologist. Striving to improve the lives of patients with cancer. May or may not be notable.
Joined July 2010
Anirban Maitra’s Tweets
Check out the Controversy and Consensus article by and Axel Behrens discussing the controversy regarding the existence and identification of #cancerstemcells.
bit.ly/3XQ5hf6
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🔥off the press: phase 1b results of CAMILLA showing Cabo plus Durva is a safe, active, & potentially synergistic regimen in MSS GI malignancies. Ongoing phase II & III trials stemming from this first report ✨✨
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Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS | Nature
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From Israel to Scotland to right here in Houston, Dr. Eyal Gottlieb has circled the globe in his quest to #EndCancer. Learn his plans for MD Anderson as our new vice president of Research: fal.cn/3vnON #Research
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Preclinical study @jclinicalinvest:
Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47 (corollary - KRAS inhibitors diminish “don’t eat me” signal on cancer cell surface).
jci.org/articles/view/
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Because of the nature of the UKCTOCS study, long standing v new onset diabetes were not reliably separated although suspect latter is what’s driving the #PancreaticCancer link.
Also, CA19-9 - for all its warts - is still the biomarker de jour to beat in PRE-diagnostic samples.
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#OpenAccess in
Serum biomarker-based early detection of #PancreaticCancer with ensemble learning
nature.com/articles/s4385
A study using PRE-diagnostic samples from the UKCTOCS study finds diabetes to be strongest clinical variable predictive of subsequent cancer.
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This is the tweetchat that inspired me to start #CRCTrialsChat. Thank you for your generosity in letting me copy this chat format & questions and for all your help to get us started.
We will have our clinical trials basics one this Thursday..
#PancChat
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Joining us tonight are our co-hosts @drallysonocean @ShaalanBeg @Aiims1742 @NirajGusani @lustgartenfdn and @PanCAN. #PancChat
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A harmonized public resource of deeply sequenced diverse human genomes
biorxiv.org/content/10.110
Thank you so much, et al!
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Our 4th most downloaded article in 2022: Targeting ferroptosis as a vulnerability in cancer by & colleagues. go.nature.com/3tZAnVv #NRCtop10of2022
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Excited to share this long gestating piece that and I've been working on. We're currently drafting a more academic version about the term "poor historian," so stayed tuned. Again, this is why #histmed matters! #MedTwitter
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How do we actualize this recommendation?
“Streamlining the GT process in medical oncology clinics by decreasing the amount of work necessary for oncologists and directly integrating germline GT into the appointment” could increase testing rates in patients with #PancreaticCancer
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Another paper on the appallingly low rates of “universal” germline testing in patients with #PancreaticCancer (which has been both & for a while now).
Only a third were tested, lower in minority patients.
In by Dr. .
ascopubs.org/doi/10.1200/PO
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Abysmally low rates of germline genetic testing in cancers like #PancreaticCancer for which universal testing has been @NCCN guideline for some time.
Germline genetic testing is standard of care, yet not sure how many oncologists are having this convo.
link.springer.com/article/10.124
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This study and it's implications for understanding intratumoral heterogeneity as a function of tissue organization...🤯If you read nothing else this week, do read the first section of the discussion.
Huge congrats to the authors! I'm in awe.
sciencedirect.com/science/articl
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#OpenAccess in
Tissue-resident memory T cells in #PancreaticCancer co-express PD-1 & TIGIT, & functional inhibition is reversible by dual antibody blockade
aacrjournals.org/cancerimmunolr
The most interesting findings here pertain to 30% of CD4 being Th17 & 17% activated Tregs
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Such an honor and surprise to be the subject of a school poster! 🤍
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@KrishnanYamuna I knew that you are a celebrity scientist but didn’t expect to see a poster on you in a school in Mumbai. Was pleasantly surprised and Loved it 
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In an #HTAN funded study, , , , Dr. Peter Sorger, et al. created a 3D #multiplexed atlas of #colorectalcancer, which revealed spatial molecular transitions and immune interactions in tumors cell.com/cell/fulltext/.
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So cool that our paper on hypoxia-mediated crosstalk between CAFs and macrophages made this list 👇
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#ICYMI be sure to check out our Top 5 high-impact basic science articles of 2022! ow.ly/9Sf850MnJPY
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We are honoring NAM and #NASmember Kevan M. Shokat of with the 2023 NAS Award for Scientific Discovery for pioneering breakthroughs in #chemicalbiology to advance cancer therapy. Congratulations! Read more: bit.ly/3ZZRJ2u #NASaward #CancerResearch #HHMI
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The winner of the 2023 NAS Award in Molecular Biology is Jason S. McLellan of ! He is being honored for pioneering work in the molecular and structural biology of viral surface proteins. Learn more: bit.ly/3Xu5GnF #NASaward #MolecularBiology
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I am so happy to work with F.McAllister & present our work on the high risk #PancreaticCancer clinic #microbiome signature at #GI23
Gammaproteobacteri oral/gut ratio represents a potential novel biomarker which could predict pancreatic focal lesions in high-risk individuals.
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New #JITC review: Liquid biopsy approaches to capture tumor evolution and clinical outcomes during cancer immunotherapy jitc.bmj.com/content/11/1/e
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Farewell to the Tiger and a warm welcome to the Rabbit! #LunarNewYear #LunarNewYear2023 #YearOfTheRabbit
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"It was only when I was diagnosed with cancer myself that I could see just how great is the distance that separates patients from doctors, and how little doctors understand about what their patients are going through.”
nytimes.com/2023/01/17/boo by
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1/ Pre-print alert! Our new study led by talented student together with illustrates that neuronal activity regulates the progression of small cell lung cancer #SCLC in the lung and brain. #CancerNeuroscience. 🧵…
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The stunningly beautiful and incredibly artistic aspect of Cytopathology preps - “Thick mucin in an IPMN”. (Diff Quik, Pancreas, FNA)
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The most promising early phase clinical trial data I have seen online from #GI23 is the aCTLA-4 / aPD-1 (colloquially Bot/Bol combo) in microsatellite STABLE #ColorectalCancer, with 23% ORR, durable responses. Substantial irAEs, as would be expected. Nonetheless…MSS!
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Inspiring #GI23 keynote by from highlighting the importance of focusing upstream to mitigate health disparities in cancer and how community engagement can help us to mitigate health disparities in cancer and cancer trials.
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How many different ways can we slice & dice Cancer-associated fibroblasts (CAFs) in #PancreaticCancer?
- myCAF / iCAF / apCAF / csCAF
- “tumor promoting” v “tumor restraining”
- in this preprint, “tumor proximal” v “tumor distal”
biorxiv.org/content/10.110
The struggle is real!
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Years ago I sat next to Mike Snyder at a study section and he was continuously monitoring various intrinsic & environmental parameters using wearables (photograph taken with permission of course).
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Continuous dynamic health monitoring (versus the current “reactive” measures) with wearables has been a longstanding pursuit at - such as this commentary by the late Sam Gambhir & colleagues
science.org/doi/10.1126/sc
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What are the molecular & metabolic consequences of having an Ensure shake? Mike Snyder addresses this and other questions using microsampling of blood paired with multi-omics profiling (“dynamic health profiling”).
nature.com/articles/s4155
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The next edition of “targeting cancer” series by features an enigmatic cell surface protein called mesothelin, overexpressed in #mesothelioma, #ovariancancer & #PancreaticCancer.
statnews.com/2023/01/20/mes
Will targeting mesothelin ever work?
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