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B would unacceptably narrow the gene pool, leading to in increase in genetic illness & disability. Also, being realistic, it's likely that the families in B would be overly religious or somehow otherwise dysfunctional & delinquent. Sorry, but I like my society secular & stable.
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Better how? Population A is 'better' prepared to survive random catastrophe, due to greater standing genetic variation. Population B is 'better' at whatever qualities are being selected for in a given mate (any n number of generations in the future).
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