I don't understand what "trans" refers to, do you mean trans people in sex work, or trans activism on a political level? And if it's the latter, do you mean as we currently observe it (read: culture war), or in general in history the principle of fighting for trans rights?
Answering this is tough. Because I genuinely don't think trans people do much damage.
But I do think activism around trans issues are doing damage and I don't know really how to appropriately react to that.
Trans people and sex work are good but their particular modern late 2010s/2020s activisms are extremely harmful and contribute significantly to an technocratic takeover of daily human life.