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For some reason, sleep deprivation (< 5 hours of sleep) just really trashes me physically. I feel like I'm dying and have about 50-50 odds of vomiting at some point during the day. Doesn't usually make me grumpy though, just sad and confused.
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I get very little sleep all the time and then work 12 hour days. It can sometimes get bad but mostly I get right through it and feel good about myself after the work day is done.