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Depends on many things - relationships, family, physical and mental health. As long as you avoid disabling injuries, addiction and psychosis, or toxic relationships,, and have enough money to live the way you want it may never really reverse.
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Yes, when the health problem start kicking in . For me that was this year at age 62 with 1) A stroke 2) Acute Pancreatitis 3) Sepsis, 4) Failed replacement knee. I now feel like a 90yo man, I used to feel like a 20yo girl - I could never catch one but I used to feel like one !