What's the difference between 'cis by default' and 'agender'?
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You're confusing gender and physical sex. We now separate physical characteristics from social expectations, behavioural factors, aptitudes, etc.
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So a trans-man or "man with XX chromosomes and a vagina" (to simplify) is someone assigned to the female gender at birth based on physical characteristics, but is more comfortable behaving and interacting in ways society generally sees as male.
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