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If you know the answer to this then you have spent way too much money at uni on a worthless degree learning about imaginary words for conditions that do not exist in reality.
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They are opposites. A person who is 'cis by default' is comfortable with their assigned gender, and would be comfortable if they had the other gender too. A person who is 'agender' is not comfortable with their assigned gender, and is also not comfortable with the other gender.
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To the former it means gender doesn't matter much (they would likely passively accept any gender identity assigned at birth); to the latter (binary) gender is something they feel strongly doesn't fit them/ describe them & actively reject it for reasons from personal to political.
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