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  1. Prikvačeni tweet
    20. sij

    I am very excited, to finally share this: Using a functional approach we uncovered a mechanism for whitening, a fundamental computation that decorrelates neuronal population activity for pattern classification by memory networks.

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  2. proslijedio/la je Tweet
    prije 19 sati

    Please RT - job opportunities - - Bio Hub 2 exciting positions opening at EMBL Heidelberg to support our activities within and

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  3. proslijedio/la je Tweet
    30. sij

    Check out this throwback of real-time brain imaging from our team! We are analyzing over 25,000 images like this, together with collaborators & supported by to map nearly a billion connections in 1mm³ of mouse brain.

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    29. sij

    We proudly present the latest addition to our online segmentation platform 3dEMtrace: Detailed cristae segmentation in mitochondria. Thanks to for providing example data!

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    Whitening of odor representations, a computation that decorrelates activity for pattern classification by memory networks, by the wiring diagram of the bulb

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  6. proslijedio/la je Tweet
    22. sij

    A Connectome of the Adult Drosophila Central Brain

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  7. 22. sij

    Beautiful connectomics work! Congratulations to the whole team!

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  8. proslijedio/la je Tweet
    21. sij
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    21. sij

    The Friedrich lab created a wiring diagram of a olfactory bulb: every neuron AND how they connect to each other via synapses. Also shown: how each neuron interacts with each other neuron to extract specific information about different smells👉

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  10. proslijedio/la je Tweet
    20. sij
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  11. 20. sij

    Targeted manipulations of the wiring diagram confirmed the proposed whitening mechanism in simulations. Hence, whitening of sensory input in the OB seem to depend on an evolutionary memory of stimulus space that is contained in the wiring diagram of neuronal circuits.

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  12. 20. sij

    Hence, MCs form cohorts of co-tuned neurons that function as feature detectors. If a particular feature or molecular property is present, the activity of the MCs in the cohort is downregulated by feedback inhibition which results in a decorrelation of related patterns.

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  13. 20. sij

    To identify properties of the wiring diagram that mediate whitening, we analyzed MC–IN–MC triplets. We found a strong over-representation of motifs with reciprocal connections and that the disynaptic inhibitory connectivity between MCs depends on their tuning similarity.

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  14. 20. sij

    The model consisted of threshold–linear rate neurons and had only 6 free parameters. With the reconstructed wiring diagram it reproduced the experimentally measured dynamics well, but shuffling the connectivity abolished both pattern decorrelation & variance normalization.

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  15. 20. sij

    Neuronal networks can decorrelate specific input patterns if their connectivity is adapted to the input covariance structure. To test the hypothesis that this transformation is encoded in the wiring diagram, we implemented a minimally complex network model of the OB.

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  16. 20. sij

    We found that the MC activity patterns evoked by chemically similar odors get reorganized within few 100ms after stimulus onset resulting in a decorrelation and variance normalization of the population activity – a fundamental computation known as whitening.

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  17. 20. sij

    We reconstructed the skeletons of all (n>1,000) neurons (see ) and annotated all synapses between the 745 mitral cells (MCs) and 254 interneurons (INs) resulting in the first synaptic resolution of an entire vertebrate brain area.

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  18. 20. sij

    Next, we acquired a complete volume electron microscopy stack of the same OB with a voxel size of 9⨯9⨯25nm and registered that EM volume to the multiphoton data for a detailed function to structure analysis of the OB circuitry.

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  19. 20. sij

    First, we measured odor-evoked neuronal activity from hundreds of neurons in the olfactory bulb (OB) of a larva using multiphoton calcium imaging.

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  20. proslijedio/la je Tweet
    17. sij

    neuPrint: Analysis Tools for EM Connectomics

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