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Prikvačeni tweet
I am very excited, to finally share this: https://www.nature.com/articles/s41593-019-0576-z … Using a functional
#connectomics approach we uncovered a mechanism for whitening, a fundamental computation that decorrelates neuronal population activity for pattern classification by memory networks.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Adrian A. Wanner proslijedio/la je Tweet
Please RT - job opportunities -
@embl - Bio Hub 2 exciting positions opening at EMBL Heidelberg to support our activities within@EuroBioImaging https://www.embl.de/jobs/searchjobs/index.php?ref=HD01704 … and@GlobalBioImage https://www.embl.de/jobs/searchjobs/index.php?ref=HD01703 …pic.twitter.com/wR8G9K5yz4
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Adrian A. Wanner proslijedio/la je Tweet
#TBT Check out this throwback of real-time brain imaging from our#ElectronMicrocopy team! We are analyzing over 25,000 images like this, together with collaborators@BCMHouston &@PrincetonNeuro supported by@IARPAnews to map nearly a billion connections in 1mm³ of mouse brain.pic.twitter.com/glC2aT106IPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Adrian A. Wanner proslijedio/la je Tweet
We proudly present the latest addition to our online segmentation platform 3dEMtrace: Detailed cristae segmentation in mitochondria. Thanks to
@priscaliberali for providing example data!#microscopy#Organoids#mitochondriapic.twitter.com/n2hjdBapFWPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Adrian A. Wanner proslijedio/la je Tweet
Whitening of odor representations, a computation that decorrelates activity for pattern classification by memory networks, by the wiring diagram of the
#olfactory bulb https://go.nature.com/2TFUczj pic.twitter.com/otJvzD86gz
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Adrian A. Wanner proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Beautiful connectomics work! Congratulations to the whole team!https://twitter.com/HHMIJanelia/status/1220010488072933376 …
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Adrian A. Wanner proslijedio/la je Tweet
Exciting week for us. Second
#connectomics study out on@biorxivpreprint focussing on#Drosophila thermosensory and hygrosensory circuits led by Lisa Marin@flyconnectome@CamZoology. Collaboration with@Nemvec@BrandeisU@dddavi@Landgraf10006 1/7 https://www.biorxiv.org/content/10.1101/2020.01.20.912709v1 … https://twitter.com/biorxivpreprint/status/1219648832658604034 …pic.twitter.com/zV1HgAWwbl
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Adrian A. Wanner proslijedio/la je Tweet
The Friedrich lab created a wiring diagram of a
#zebrafish olfactory bulb: every neuron AND how they connect to each other via synapses. Also shown: how each neuron interacts with each other neuron to extract specific information about different smells
http://bit.ly/2NJZB4D pic.twitter.com/o6rqSrsHbq
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Adrian A. Wanner proslijedio/la je Tweet
Excited to share our
@biorxivpreprint:#connectomics reconstruction of olfactory circuits in the#Drosophila brain led by@as_bates@MRC_LMB,@uni_matrix@martamcosta2@CamZoology. Collaboration with@ddavi,@ScottishWaddell, Gerry Rubin@HHMIJanelia 1/12 https://www.biorxiv.org/content/10.1101/2020.01.19.911453v1 …pic.twitter.com/HxzhfWT5Pt
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Targeted manipulations of the wiring diagram confirmed the proposed whitening mechanism in simulations. Hence, whitening of sensory input in the OB seem to depend on an evolutionary memory of stimulus space that is contained in the wiring diagram of neuronal circuits.pic.twitter.com/zu8lujcsw7
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Hence, MCs form cohorts of co-tuned neurons that function as feature detectors. If a particular feature or molecular property is present, the activity of the MCs in the cohort is downregulated by feedback inhibition which results in a decorrelation of related patterns.pic.twitter.com/NxW5KlsC73
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To identify properties of the wiring diagram that mediate whitening, we analyzed MC–IN–MC triplets. We found a strong over-representation of motifs with reciprocal connections and that the disynaptic inhibitory connectivity between MCs depends on their tuning similarity.pic.twitter.com/UzBHo2lqvk
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The model consisted of threshold–linear rate neurons and had only 6 free parameters. With the reconstructed wiring diagram it reproduced the experimentally measured dynamics well, but shuffling the connectivity abolished both pattern decorrelation & variance normalization.pic.twitter.com/cYp1CimzfK
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Neuronal networks can decorrelate specific input patterns if their connectivity is adapted to the input covariance structure. To test the hypothesis that this transformation is encoded in the wiring diagram, we implemented a minimally complex network model of the OB.
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We found that the MC activity patterns evoked by chemically similar odors get reorganized within few 100ms after stimulus onset resulting in a decorrelation and variance normalization of the population activity – a fundamental computation known as whitening.pic.twitter.com/hHUMiuJFBh
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We reconstructed the skeletons of all (n>1,000) neurons (see https://www.nature.com/articles/nn.4290 …) and annotated all synapses between the 745 mitral cells (MCs) and 254 interneurons (INs) resulting in the first synaptic resolution
#connectome of an entire vertebrate brain area.pic.twitter.com/w9ucYOgLfkPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Next, we acquired a complete volume electron microscopy stack of the same OB with a voxel size of 9⨯9⨯25nm and registered that EM volume to the multiphoton data for a detailed function to structure analysis of the OB circuitry.pic.twitter.com/2oIQpSwrEd
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First, we measured odor-evoked neuronal activity from hundreds of neurons in the olfactory bulb (OB) of a
#zebrafish larva using multiphoton calcium imaging.pic.twitter.com/n9Ry0pKo7GPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Adrian A. Wanner proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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