@AdamMarblestone @s_r_constantin All these clocks are looking at CpG methylation. But.. non-CpG methylation is also a thing, and seems to matter in the brainhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3785061/ …
Cool. And can CRISPR activate or inactivate other genes while you’re at it if you think there is more that needs to happen than methylation changes, to drive the system. A few orthogonal Cas9’s engineered in but many mice getting many different cocktails of gRNAs at embryo stage!
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p.s., of course in addition to methylation there are lots of other epigenetic assays like HiC, transcriptome itself, and so on... which could maybe make clocks... maybe an exosome RNA clock...
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Add persistent maintenance of the DNA encoding your gRNAs but make it all drug inducible and you have a hell of a platform for combinatorial i/o for aging
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