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AdamMarblestone's profile
Adam Marblestone
Adam Marblestone
Adam Marblestone
@AdamMarblestone

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Adam Marblestone

@AdamMarblestone

Technologist, Scientist

adammarblestone.org
Joined February 2009

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    1. Grace Lindsay‏ @neurograce Apr 6
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      Replying to @gottapatchemall @schoppik and

      That sounds great!

      1 reply 0 retweets 1 like
    2. Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @neurograce @gottapatchemall and

      Was proposed here as well: http://blogs.cuit.columbia.edu/rmy5/files/2017/06/brain_observatory_paper.pdf … Strong agree. I just don’t see how certain key tech can be built otherwise. Would remain 1000s of individual labs too as you say.

      2 replies 0 retweets 2 likes
    3. Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @AdamMarblestone @neurograce and

      In general in bio, I see a big gap in the funding of 20-100 M$ scale projects to develop tech or infra to collect data we want. Of which several are needed. Examples: Etruscan shrew connectome, screen all combos of aging drugs/factors, scale up sc-proteomics tech, etc @ArtirKel

      1 reply 0 retweets 5 likes
    4. Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @AdamMarblestone @neurograce and

      There is no reason we should think the complexity of biological systems is magically perfectly matched to the contingent sociological happenstance of our current dominant organization of science intensive engineering and engineering intensive science!!!

      3 replies 1 retweet 13 likes
    5. john sakon‏ @jjsakon Apr 6
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      Replying to @AdamMarblestone @neurograce and

      Interesting to think of that deficit in terms of human brain capacity. As in how a single person can only grasp what ~100 people are doing at a time. Projects getting into the $20-100m range approach that cognitive bottleneck, so real organizational (industrial) know-how needed

      1 reply 0 retweets 3 likes
    6. Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @jjsakon @neurograce and

      Yes! Needed. But see for instance Intel, or LIGO, or CERN

      2 replies 0 retweets 1 like
    7. Shahab Bakhtiari‏ @ShahabBakht Apr 6
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      Replying to @AdamMarblestone @jjsakon and

      I would like to know more about the equivalent of theoretical basis that supported LIGO/CERN type of organizations, in neuroscience.

      1 reply 0 retweets 1 like
    8. Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @ShahabBakht @jjsakon and

      One of the biggest missing factors I think, yeah — that clarity of what to measure / test

      2 replies 0 retweets 2 likes
    9. john sakon‏ @jjsakon Apr 6
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      Replying to @AdamMarblestone @ShahabBakht and

      Yeah, people often make point that physics is centuries old, while neuroscience is really only at decades. So if we don’t know what basket to throw our eggs in, at least not nearly as well as physics (hence Blue Brain disaster), the many small labs exploratory model makes sense

      2 replies 0 retweets 1 like
    10. Shahab Bakhtiari‏ @ShahabBakht Apr 6
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      Replying to @jjsakon @AdamMarblestone and

      I’m a big fan of the type of data coming out of Allen, but as someone working with their data in daily basis (mainly brain observatory), very basic questions such as “why this type of stimulus and not something else” is quite ambiguous.

      2 replies 0 retweets 1 like
      Adam Marblestone‏ @AdamMarblestone Apr 6
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      Replying to @ShahabBakht @jjsakon and

      Hence more of this kind of thing, not less, imho

      3:16 PM - 6 Apr 2020
      2 replies 0 retweets 0 likes
        1. john sakon‏ @jjsakon Apr 6
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          Replying to @AdamMarblestone @ShahabBakht and

          Indeed, probably the right tool for some jobs. I’m now utilizing fruits of what $24m bought so can’t complain https://www.sciencemag.org/news/2014/07/darpa-awards-40-million-restore-memories … And I think it was fair to think ~2014 was the right time to try this approach at that scale. Now we can measure effects at 5-10x the usual power

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        1. Shahab Bakhtiari‏ @ShahabBakht Apr 6
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          Replying to @AdamMarblestone @jjsakon and

          Yeah ... I see your point. Hopefully in future they’ll have higher capacity to run more experiments tailored to different goals/questions.

          0 replies 0 retweets 1 like
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