Finished this — a must read... really really interestinghttps://twitter.com/ArtirKel/status/1219393786767429634 …
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Replying to @AdamMarblestone
I just found that maybe reprogramming does reduce lipofuscin concentration after all, if only by dilution. And rapamycin, surprisingly, also seems to clear it out https://www.sciencedirect.com/science/article/pii/S0531556516302376?via%3Dihub …: https://www.leafscience.org/is-comprehensive-damage-repair-feasible/ … (comtrol-f it)
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Replying to @ArtirKel
@LauraDeming Interesting. Though, not sure I buy “dilution“ all the way — suppose it is a non-dividing brain cell? Even if another tissue will reprog always -> dilution. BTW what happens to telomeres upon epigenetic reprog!? Maybe Yamanaka cycles + rapamycin + something 4
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Replying to @AdamMarblestone @LauraDeming
I wouldn't either; also lipofuscin would still accumulate in the extracellular matrix eventually. But yes, I think someone should there grab a bunch of mice and do the all in one combo and see how long they live. I wonder if any of these rejuvenation techniques affects in any way
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The storage of memories
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Replying to @AdamMarblestone @LauraDeming
Who would be happier
@AdamMarblestone with brains and tools to measure them or zombies with lots of brains to eat1 reply 0 retweets 0 likes
True. Things other than brain wiring are at least an easier measurement problem — you can measure telomeres in one little chunk of liver, histone meth in another and lipofuscin in a third and have a chance these are “IID samples“ of the same tissue in a way...
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