I just found that maybe reprogramming does reduce lipofuscin concentration after all, if only by dilution. And rapamycin, surprisingly, also seems to clear it out https://www.sciencedirect.com/science/article/pii/S0531556516302376?via%3Dihub …: https://www.leafscience.org/is-comprehensive-damage-repair-feasible/ … (comtrol-f it)
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@LauraDeming Interesting. Though, not sure I buy “dilution“ all the way — suppose it is a non-dividing brain cell? Even if another tissue will reprog always -> dilution. BTW what happens to telomeres upon epigenetic reprog!? Maybe Yamanaka cycles + rapamycin + something 4
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