Are cortical excitatory synapses analog or discrete? Being able to analyze 1000’s of synapses from a proofread EM volume finds evidence for two states, one bigger than the other. 1st analysis paper from our EM data, led by @sdorkenw, @SebastianSeung et al!https://www.biorxiv.org/content/10.1101/2019.12.29.890319v1 …
And they qualify it with “at least in part”, which leaves open that at least some learning may be intracellular!
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they do, but "at least in part" part is still without a reference..
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That could probably cite a broad swath of Kristin Harris’s work, among others. e.g. results reviewed here: http://synapseweb.clm.utexas.edu/sites/default/files/synapseweb/files/2007_curr_opin_neurobiol_bourne_harris_do_thin_spines_learn.pdf …
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