Trying to figure out what technology progression (ie transistors per $, genes sequenced per $, material costs per mm^3 in 3D printing, etc) will advance the quickest and most exponentially in the 2020a. Embarrassed I lack conviction so far. Anyone with a well-informed opinion?
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Replying to @m2jr
Genetic drugs! A whole class of diseases & maladies that have been largely undruggable for all of humanity are now druggable with gene therapy, RNAi, etc. Still lots of work to do here on COGS, delivery etc but the potential to fix, not slow/dampen some diseases is momentous!
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Replying to @celinehalioua @m2jr
Is there an underlying trend behind these (like sequencing or imagine or something getting cheaper) or is it a combination of different discoveries?
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Good Q, I've been reading a subset of this literature (cellular reprogramming, OSKM transcription factors) but haven't focused in the genealogy of it!
@AdamMarblestone pointed me to a startup that's developing that into a drug ,http://turn.bio1 reply 0 retweets 4 likes -
Replying to @ArtirKel @Ben_Reinhardt and
I think it’s more about clinical validation - multiple genetic drugs have been FDA approved in the last two years, demonstrating safety and efficacy
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Replying to @celinehalioua @Ben_Reinhardt and
So then that reduces regulatory risk for newcomers?
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I agree with Celine but would add in-situ epigenomic measurement, which is complementary as a technology — to know what to target with all this: https://studyres.com/doc/22052027/in-situ-technologies-enable-a-pan-omic-human-cell …
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