At 1 mm^3 / day, the human connectome would take ~3,500 years to image. The fastest EM approach (GCIB-SEM) is currently at 1 mm^3 / month. I suggest that we need an entirely new imaging paradigm to overcome this challenge! This is the challenge that my research focuses on.
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Interesting, I definitely agree that the molecular content is important and that barcoding would help decrease the necessary voxels. I still think that the approach of getting 1,000 GCIB-SEMs might lack efficiency/cost-effectiveness since it is very brute force oriented.
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If we want to do comparative connectomic studies across many human brains, we might benefit from much faster and potentially less costly technology as well. Perhaps Tweets aren't the ideal place to discuss this though, do you want to switch to PMs?
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