I don't disagree this is a useful line of inquiry. But with all we're learning about cell types and cell/compartment-specific interactions in the brain, it seems likely there is a mechanistic basis of neural computation yet to be discovered.
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In theory could do it by endlessly tweaking multi-compartmental models, but...
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At least until recently,
@AllenInstitute was heavily invested in biophysical modeling constrained by rich neural data. Important approach, but also a long and difficult game when played at the scale of cortical systems. - 2 more replies
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