Neuroscience thought problem: Someone gives you simultaneously recorded spike trains (ms resolution) from every neuron in a region of the brain under multiple task conditions. No connectome. What analysis tools do you deploy to study mechanisms by which circuits support behavior?
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I don't disagree this is a useful line of inquiry. But with all we're learning about cell types and cell/compartment-specific interactions in the brain, it seems likely there is a mechanistic basis of neural computation yet to be discovered.
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Yep and I personally doubt we’ll see either the opt mechanism (if any) or the more specific computational built-ins you’re referring to, with pure recording minus perturbation and connectomics.
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