A leading geneticist recently asserted to me that we can store a person's genome in ~2 megabytes simply by encoding all deviations from a complete reference genome. Curious if others see any caveats, and what challenges for analysis this approach might present?
0.02 bits per base = 10 megabytes here buthttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083090/#__ffn_sectitle …
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That is the diff to human reference genome. The diff to my father an smother is *much*. The diff to drosophila much bigger.... The entropy of the reference genome is quite high.
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