Sewing-machine insertion of flexible electrodes via small holes. Good progress on channel count + insertion, building on @m8ta's work. Also nice chip+packaging. Hard stuff. Much depends on gliosis, but Chong Xie's results promising. Laser would indeed be preferable to drill. 1/4https://twitter.com/antonioregalado/status/1151335093354582016 …
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Replying to @AdamMarblestone @m8ta
if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here...1 reply 1 retweet 3 likes -
Optical readout has problems too. Need to express sensor genes stably and safely. Can't see more than 200um deep without 2-photon, which is not getting minaturized to a wearable probably ever. Even with 2p, can't get over 700um deep. Implantable lenses cause huge damage...
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2-photon and sensor genes are not the only options here...
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...unless you want cellular resolution instead of measuring blood flow/oxygenation...
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Willing to consider other plausible mechanisms with citation. (e.g. photoacoustic imaging of activity dependent contrast agent with resolution enhanced via adaptive optics corrected by ultrasound-induced cavitation guidestars...). A TED talk is not a citation. What u got?
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Agreed. I wish we could continue this in detail...! There are a lot of smart people thinking outside the box at Kernel and elsewhere though...
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