Demo is far from major human medical apps, though, e.g., How to access subcortical structures where DBS is done? Presumably, just add a traditional DBS lead. Any large/mass-market med. indications that need all these channels? DARPA sees alt. future: https://www.darpa.mil/program/next-generation-nonsurgical-neurotechnology … 2/4
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Should emphasize that chronic flexible electrode problem has vexed researchers for decades, so if a solution proves out it will accelerate BCI field and drive more advances w/ electrodes. Nice 4 neuroscience, as was Neuropixels. Could be good for paralysis. But very invasive. 3/4
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Neuroscience is hard enough that integrated, multidisciplinary, focused engineering efforts (& new cultural frames) like this are needed -- this is impressive demonstration of that. So go Neuralink!!! But think carefully if this is the true path... Looking fwd to your papers! 4/4
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if you’re putting electronics inside the skull, flexible electrodes will lose long term to optical readout. Nearly all hard problems unsolved here, animal model doesn’t translate (vasculature, insertion depth), hermeticity, reg burden unproven. Feel like we’ve been here... -
Optical readout has problems too. Need to express sensor genes stably and safely. Can't see more than 200um deep without 2-photon, which is not getting minaturized to a wearable probably ever. Even with 2p, can't get over 700um deep. Implantable lenses cause huge damage...
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