Note: there is still very little test data available pre-symptoms, so bear this uncertainty in mind when interpreting these results.
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A comparison for limits of detection are needed among the various assay kits on the market as we should expect some platforms will exhibit greater sensitivity than others.
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UW virology already did this (in fact two PCR test comparison papers came out of the UW Seattle). Both on Medrxiv, IIRC.
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Enormous error bar suggests small n. How representative were the subjects? What if you combined saliva+nose+throat for more info? What is correlation between person being infectious early and testing +ve? E.g. do people shedding more early test +ve more?
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It's a meta-analysis.
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Austria (and maybe other countries) let you circumvent the quarantine if you do a swab test. Do these results suggest this may not be a safe strategy? That people need to be quarantined for say 3 days and then take the test?https://www.telegraph.co.uk/travel/news/austria-vienna-airport-coronavirus-covid-19-test/ …
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You still get a lot of Bayesian evidence from swab test, because someone could be at any stage of disease progression. If prior is low (<1% person is infected), you might get odds ratio 3-6 from swab test, and so that could be enough. Or do 2 day thing
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Do you think travelers & close contacts should complete a 14-day quarantine regardless of their initial test results?
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I know of 3 people who had negatives with strong covid symptoms - one who after 2 negatives had a positive & died, other 1 an A&E nurse & the other the sats & symptoms led A&E to conclude covid19 despite -ve test - v poorly
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Any studies on the likelihood of being negative in the antibody test even though being infected (given mild or difficult case)? Or likelihood of getting reinfected if negative in the antibody test?
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The likelihood would be ~100% until the adaptive immune response kicks in (> one week), later apparently very low. I guess nobody knows yet about reinfections? https://www.medrxiv.org/content/10.1101/2020.04.30.20085613v1 …
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