This work represents my favorite scientific experience of my career. Not because of the findings or where published, but because of the underlying team effort.https://gph.is/1sz969A
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It started almost 10 years ago. When I was opening my lab, I got a job inquiry from a patch clamper named Jay Guo https://www.janelia.org/people/jian-zhong-guo … at George Washington. Little did Jay know, I was transforming my lab and no longer doing slice electrophysiology.
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I politely told him his skillset was not what I was looking for but he could help set up the lab for 6 months. That was nearly a decade ago! What I did not know was that Jay was not a patch clamper, he an experimentalist extraordinaire as well as a phenomenal human being.
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1 of many experiments Jay did over the last 10yrs was to show the necessary/sufficient role of rodent motor cortex for controlling dexterous behavior. This not only identified a cortically dependent motor action in the rodent, but it also gave us a lot of optogenetic experience.
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But we had not used e-phys to really understand what was going on. Fortunately, as we were dreaming up experiments,
@bsauerbrei1 joined us. If anyone knows Britton, they know at least two things: he loves rigorous analysis and has undying devotion to the cerebellum.pic.twitter.com/XOQo5KWtqB
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Despite his pathological obsessions with the “little brain”, I somehow convinced Britton to join Jay on the project. As always, we had our wonderful collaboration with the Branson lab and analysis efforts were further bolstered with the addition of Matteo Mischiati to the lab.
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However, the cast of characters of this study was not quite complete. As this study went on, our initial hypothesis that cortex was an autonomous dynamical system was looking erroneous. The results were begging for a set of extremely difficult experiments involving the thalamus.pic.twitter.com/DkPpnRShpz
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This is when we called in our ‘Canadian Special Weapon’, Jeremy Cohen. Jeremy is famous for doing extremely difficult experiments. Jeremy performed two absolutely essential experiments which provided the last convincing bits of data for the paper.pic.twitter.com/OvQNnEwh1T
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Ok, so a long way of describing the greatness of my collaborators. And, of course, many thanks to Janelia
@HHMIJanelia and@HHMINEWS which made it all possible.https://gph.is/KqRozhPrikaži ovu nit -
One last contribution. Want to extend deep gratitude to I-han
@ih_C_hi our Nature Editor for sticking with us as well as our extremely useful reviewers (including@jesseGlab) who kept pushing us.Prikaži ovu nit
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