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  1. 3. velj

    Here's a video abstract of our recent work on sensory processing in cortical Layer 1. Some pure speculations at the end about relevance to Yerkes-Dodson law! , , , ,

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  2. 24. sij
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  3. 23. sij

    We don’t know whether this symmetry breaking is what really happens, or if the cells that go nuts are somehow special.

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  4. 23. sij

    A computational model showed that even if all the cells were almost identical, strong cholinergic activation of all neurons would drive a winner-takes-all symmetry breaking, where just a few neurons spike quickly, and suppress their neighbors.

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  5. 23. sij

    Cholinergic activation via an air puff causes sporadic spikes in most L1 interneurons, but a few cells go nuts. Why?

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  6. 23. sij

    Optogenetic silencing of L1 interneurons in a ring blocks the sensory-evoked inhibition in a central neuron. (Surprise! A new optogenetic construct, i-Optopatch, pairing GtACR2 and Archon1).

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  7. 23. sij

    Optogenetic stimulation of L1 interneurons in a ring induces inhibitory responses in a central neuron that look just like the sensory-evoked inhibition.

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  8. 23. sij

    The inhibition is normally invisible because the resting potential is too close to the chloride reversal potential. Optogenetic depolarization increases the driving force for chloride, revealing the otherwise invisible inhibitory signals.

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  9. 23. sij

    Thalamic inputs excite L1 interneurons. But then these neurons inhibit each other.

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  10. 23. sij

    Whisker stimuli have *opposite* effects on membrane potential in L1 interneurons, depending upon whether paired with optogenetic stimulation. How can that be? Led by , great collaboration with Anne Takesian and labs.

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  11. 21. sij

    Do ion channels uniquely set the membrane voltage? Can bioelectrical patterns emerge in homogeneous tissues? Come for the electrophysiology and dynamical systems, stay for the developmental biology! Fun collaboration with lab:

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  12. 22. pro 2019.

    Here's a video discussion of work by on cell membrane mechanics. Pardon the glitchy delivery. Mmm, Jello....

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  13. 13. pro 2019.

    Zheng does a really nice job explaining our recent review on cell membrane mechanics. Mmmm, Jello....

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  14. 3. stu 2019.

    Ontogeny recapitulates phylogeny?

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  15. 31. lis 2019.

    Since you asked: the protein is Kaede, photo-activated on an ultrawide-field structured illumination microscope (), and imaged via Hadamard microscopy (). Un-converted Kaede in orange, converted in green.

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  16. 31. lis 2019.

    Happy Halloween! World's smallest fish-o-lantern? Four zebrafish embryos expressing a photo-activated fluorescent protein, patterned activation via a digital micromirror array. Credit: Harry McNamara.

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  17. 10. lis 2019.

    Congratulations to Vicente Parot on receiving the Thomas F. Deutsch Fellowship from the Optical Society of America! Great job, Vicente!

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  18. 13. ruj 2019.

    Congratulations to Harry McNamara and on both defending their theses! So cool to hear about synthetic electrophysiology (Harry), optical control of embryonic development (Harry), and optical electrophysiology in cortical layer 1 (Linlin) all in one week! Dr., Dr.!

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  19. 19. lip 2019.

    Oh--and we're looking for postdocs! Email me if you want to apply the latest and greatest voltage imaging tools to study circuit dynamics in vivo.

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  20. 19. lip 2019.

    And here's a companion paper with Carlos Sing-Long describing an extension of the technique to high-speed imaging via compressed sensing:

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