2/7 Our study probes cancer-specific exon-exon junctions using archived human RNA-seq data spanning TCGA, GTEx and selected noncancer samples from SRA.
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3/7 When are exon-exon junctions detected in TCGA cancer samples cancer-specific?
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4/7 For insight, we looked at various degrees of exon-exon junction novelty: 1) junctions not in GTEx or TCGA tissue-matched normal samples 2) junctions not in any GTEx or TCGA normal ("core normal") samples 3) junctions in neither core normals nor selected SRA noncancer samples.
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5/7 We found that after removing exon-exon junctions in GTEx and TCGA tissue-matched normal samples from consideration, 80% of junctions across TCGA were still found in other normal GTEx tissues.pic.twitter.com/pzkafGA2Bj
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6/7 We further found that many cancer-specific junctions in neither core normals nor selected SRA noncancer samples recur across TCGA cases and cancer types.pic.twitter.com/qc2hgIPtfh
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7/7 Finally, some cancer-specific junctions are found in developmentally associated samples!pic.twitter.com/ewIpbtcNWH
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Wow. Really impresive study
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I would be happy to discuss further if you have any questions about what we found!
Kraj razgovora
Novi razgovor -
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Very excited to see it -- congrats to everyone!
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Thank you!
Kraj razgovora
Novi razgovor -
Čini se da učitavanje traje već neko vrijeme.
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