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Econs new to mendelian randomization IVs: this is a great paper to start learning from. Very good methods explanations. Unfortunately, the within-family analysis, which actually leverages the "randomization" part of "Mendelian randomization," is too imprecise for conclusions.https://twitter.com/JHealthEcon/status/1225086680241229826 …
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...it turns out that if the proportional hazard assumption holds in a model with covariate adjustment, it means the same assumption doesn't hold when covariates are not included in the model. That's all for now. I'll keep digging on this in the future.
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...that power improvements in Cox do occur with covariate adjustment, but because Cox estimates are biased(!) toward null in the absence of including appropriate covariates. Also...
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Novice here, but the more I'm reading, the more I'm concerned about Cox, which again is the current bedrock of clinical trial analysis. Readings like these are a bit sobering and seem to suggest... https://www.sciencedirect.com/science/article/abs/pii/S0197245697001475 … https://onlinelibrary.wiley.com/doi/pdf/10.1002/sim.4780140804 … https://www.jstor.org/stable/pdf/2336553.pdf?casa_token=HXX-oJCAAuEAAAAA:VZNAftgFjHjs1KgLaEhhZnhtg_AB7rU8S48SpD2j7G6iWRzem_lLzLeKe2NTVwUyWgeRv2DZRO50lbAkR0UFxL2ieOi0APYXK4aWI98usGECBVmrCd8Z …
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Metrics/stats twitter: I'm seeking intuition for a puzzling aspect of Cox hazard models, nowadays the main method for assessing medical treatment effectiveness in trials. Adjusting for covariates doesn't improve power in balanced experiments. Why? (Formula from Stata manual)pic.twitter.com/ms2SGFS8bQ
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Aaron Schwartz proslijedio/la je Tweet
Important work on overestimated surgical global period RVUs by Mulcahy Merrill
@Ateevm https://www.nejm.org/doi/full/10.1056/NEJMp1908706?query=featured_secondary …@NEJM Maybe@CMSGov spends too little on admin, leaving Medicare PFS susceptible to regulatory capture by interest groups (eg, RUC).pic.twitter.com/4l2fmcqhSk
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Behavioral economist on why you shouldn’t get AppleCare for your new iPhone.https://twitter.com/Devin_G_Pope/status/1219404977204072448 …
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Nice example of RCTs yielding very different results. Two NEJM studies on smoking cessation interventions: Study #1: https://www.nejm.org/doi/full/10.1056/NEJMoa1808779 … e-cigs -> 18% quit nicotine replacement -> 10% quit Study #2: https://www.nejm.org/doi/full/10.1056/NEJMsa1715757 … e-cigs -> 1% quit nicotine replacement -> 0.5% quit
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Aaron Schwartz proslijedio/la je Tweet
Harvard Alert: The individual has been apprehended and is in custody. The shelter in place is lifted.
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Aaron Schwartz proslijedio/la je Tweet
Harvard Alert HUPD and CPD officers responding to a report of a male with a gun in the area of Smith Campus Center. Shelter in place. If outside go inside a Harvard building. If in a building stay where you are.
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Aaron Schwartz proslijedio/la je Tweet
Very happy to finally post a version of a WP with Maxim Pinkovskiy and @jwswallace, studying the impact of Medicare of consumer finances across the United States. https://paulgp.github.io/papers/GPW_compressed.pdf … There's a lot in this paper, and we'd love feedback. Especially on the methods! Thread
pic.twitter.com/oGOfN9jQXw
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Aaron Schwartz proslijedio/la je Tweet
Our new
@AnnalsofIM paper (w/@JMichaelMcW +@Michael_Chernew): patterns of turnover in the physician workforce likely contribute to provider consolidation. (1/7) https://annals.org/aim/article-abstract/2758850/physician-organization-role-workforce-turnover …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Aaron Schwartz proslijedio/la je Tweet
Deaths of despair? 5 years after auto assembly plant closures, affected counties saw an 85% relative increase in
#opioid overdose mortality rates. Disproportionate effect on young, non-Hispanic white men. Findings from@atheendar in@JAMAInternalMed. More
https://bit.ly/2FsefbX pic.twitter.com/Ok148cgzh9
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Aaron Schwartz proslijedio/la je Tweet
https://www.marketwatch.com/story/millions-of-children-receive-unnecessary-medical-care-including-prescription-drugs-cervical-cancer-screenings-and-antibiotics-2020-01-08 … Really nice write-up of our recent paper on low-value care in children - with lots of tips on how parents can minimize the chance their children receive this care.
#tweetiatrician@contirena1@A_Schwa@annavolerman@UMchear https://pediatrics.aappublications.org/content/early/2020/01/06/peds.2019-2325 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
PS- this is general speculation about interventions for complex patients. On the specific question of whether targeting the tail of the spending distribution is the best way to reduce wasteful spending, Michael and I wrote on this earlier.https://twitter.com/JMichaelMcW/status/1215048335523864577?s=20 …
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Who knows whether this phenomenon explains the null result for the Camden hot-spotting study, or explains the many high profile nulls in ICU medicine. But, I do think it's something we should keep in mind in designing and evaluating interventions for complex patients. (End)
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Even interventions that help produce a "win" will fail to improve patient outcomes if the desired outcome depends on everything else going right. (6/7)
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When caring for very sick patients, or reading about randomized trials for very complex patients, I often think about this paper. For these patients to succeed, they need a series of "wins" without any "loss". (5/7)
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The paper was named for the faulty component causing the Challenger spaceship disaster. The model described economic output as depending on a series of complement tasks, any one of which could fail, rendering the others useless. (4/7)
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These discussions remided me of the work of Michael Kremer, who won the econ Nobel this year. In 1993, just out of grad school, he published a paper on what he called "The O-Ring Theory of Economic Development". (3/7 ) https://www.jstor.org/stable/2118400
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