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Find
#nCoV2019 updates and ASM#coronavirus materials on our Coronavirus Resource page:https://skyw.io/UzbkEoHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Evolution of rhizobial lineages was replayed in an evolution experiment where plant pathogen Ralstonia solanacearum evolved the capacity to nodulate and invade Mimosa pudica. The improved infection required the Phc quorum sensing system.
@mBiojournal https://skyw.io/iP7qKN pic.twitter.com/enqMQ9m5gn
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ASM proslijedio/la je Tweet
Colistin AST w/ disk diffusion and gradient strips performs poorly. Previous results showed that use of calcium-enhanced agar improved results with mcr-1 isolates. Is this method appropriate for use with non-mcr-1 isolates? Nope. https://jcm.asm.org/content/58/2/e01522-19 …
@ASMicrobiologypic.twitter.com/FRVE5Xl00H
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A nonsecreted cell wall protein is required to promote the early epithelial transmigration of human neutrophils into the airspace in response to A. fumigatus.
#IAIJournal https://skyw.io/m3l4eG pic.twitter.com/XgL8UdwTwq
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Hemagglutinin destabilization decreased virulence of H1N1 influenza virus in mice by boosting early infection in DCs, resulting in the greater activation of antiviral responses, including the type I IFN response
@JVirology https://skyw.io/pIJkWH pic.twitter.com/THuCunUHSN
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The magnetoskeleton and optimal positioning of magnetosome chains are required for efficient magnetotaxis in Magnetospirillum gryphiswaldense.
@AppEnvMicro https://skyw.io/vAQWU1 pic.twitter.com/LFx200pIFR
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For a broader overview on
#coronavirus virology, epidemiology, and discussion of the ongoing#2019nCoV outbreak, listen to recent#TWiV episodes featuring Ralph Baric speaking with@profvrr:https://asm.org/Podcasts/TWiV/Episodes/Year-of-the-coronavirus-TWiV-584 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Tim also discusses his work on hepatitis C virus and his career journey from academia to industry and back to academia. Download or stream to listen to the latest
#MTM today:https://asm.org/Podcasts/MTM/Episodes/Coronavirus-Antiviral-Drug-Discovery-with-Timothy …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Studies suggest a high genetic barrier to resistance, but it's an important aspect to consider in moving to human treatment. Tim: “I don’t think we can ever stop developing antiviral drugs...you really need to be thinking 2 or 3 steps ahead.”
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Remdesivir has already been studied in people: “If you have an experimental drug treatment, you can do experiments in cell culture or in mice, but you still don’t know if it’s safe in people. Remdesiver has already gone through Phase I, so we already know it’s safe in people."
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Tim has studied Remdesivir in mice, a close but not identical animal model of disease. CoV disease in people takes place over a course of about 2 weeks. In mice, the disease is similar, but progression is faster, taking about 1 week.http://dx.plos.org/10.1371/journal.pone.0220126 …
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Remdesivir works against every coronavirus tested so far, including viruses with the most divergent RDRP sequences (nsp12 below). The gene for RDRP is more highly conserved than the gene for the spike glycoprotein https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567817/ …pic.twitter.com/EK4uKuokic
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One drug Tim studies is remdesivir (RDV), a nucleoside analog that inhibits the coronavirus RNA-dependent RNA polymerase (RDRP). Note: Tim has not looked at RDV inhibition of 2019-nCoV, but similarity of 2019-nCoV to other coronaviruses makes RDV a promising inhibitorpic.twitter.com/e0yrAGTD8a
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SARS-CoV prefers ciliated epithelial cells and uses ACE2 as its receptor. MERS-CoV prefers nonciliated epithelial cells and uses DPP4 as its receptor. [2019-nCoV appears to use ACE2 as its receptor: https://jvi.asm.org/content/early/2020/01/23/JVI.00127-20 …]
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Tim studies coronaviruses using differentiated ex vivo cultures, which allow the study of virus infection in a 3D model representation, including target cell types of both MERS-CoV and SARS-CoV.
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bycA is a negative regulator of hyphal growth and/or a positive regulator of yeast growth in Mucor. Calcineurin suppresses expression of the bycA gene at the mRNA level to promote hyphal growth
@mBiojournal https://skyw.io/orDvYG pic.twitter.com/YZrARwOUaZ
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ASM proslijedio/la je Tweet
A Multicenter Study of the Revogene C. difficile System for Detection of the Toxin B Gene from Unformed Stool Specimens http://ow.ly/ZXDk50ycq8e
@ASMicrobiology#ASMClinMicroHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Are there drugs to treat
#coronaviruses? Timothy Sheahan talks about his drug discovery work on a compound that inhibits all coronaviruses thus tested, and how his career path took him to pharmaceutical research + back to academia. Listen today: https://skyw.io/KfgqUx#nCoV2019Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
The Anaplasma phagocytophilum adhesin, Asp14, binds and brings protein disulfide isomerase proximal to surface disulfide bonds that it reduces and enables cellular and in vivo infection.
@mBiojournal https://skyw.io/OKvMzL pic.twitter.com/Vc8kKOTnoA
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Those working with
#nCoV2019 aren't in the dark on proper precautions: previous#coronavirus outbreaks have allowed guidelines for the current outbreak to be quickly distributed for healthcare worker safety. More from@RodneyRohde: https://skyw.io/BbCP8g#ASMClinMicroHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
In H. pylori, the 3 Cag ATPases have nonredundant functions required for CagA delivery. The energetic requirements for phenotypes associated with intracellular entry of nonprotein constituents differ from that for translocation of CagA.
#IAIJournal https://skyw.io/1hItA8 pic.twitter.com/u874DSVHE1
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