time for another #tweeprint:
This #preprint about a particular SHAPE of seizure is live:https://www.medrxiv.org/content/10.1101/2020.01.09.20017053v1 …
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First, early discharges are more broadly spatially distributed on ECoG, even more widespread than the later discharges that are associated with intense action potential firing, and phase-locked high frequency LFP that indicates seizing brain tissue.pic.twitter.com/EBYTLzHHxU
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Note the clear narrowband gamma peak in the above spectrogram, and the increased broadband high frequency LFP after about 40 seconds. The narrowband gamma doesn't distinguish seizing brain tissue, but the broadening of the spectrum in later discharges does.pic.twitter.com/WQ4VjEySdC
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We show this spectral broadening associated with seizing brain tissue can be clearly observed in the spectrum, or measured for each discharge in a seizure using information theoretic quantities.pic.twitter.com/EdPmeOmfmT
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Finally, back to that narrowband gamma, we show that action potentials measured on the microelectrode arrays differentially couple to narrowband gamma before and after the neuronal signature of recruitment into a seizure.pic.twitter.com/rgTOwKtloB
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These analyses were inspired by work from
@LMPrida's lab and further confirm that broadening of the high frequency LFP spectrum is associated with increased population neuronal firing under an electrode, even if that electrode may not be able to record action potentials.Prikaži ovu nit -
These results further emphasize the importance of examining the high frequency LFP spectrum to contextualize seizure recordings in epilepsy research and point to broadband high frequency LFP's utility for understanding seizure mechanisms in the clinical setting.
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