Elliot Smith

@50kDinar

research faculty studying human neurons, epilepsy, and neural prostheses; also musician. He/him.

Salt Lake City, UT
Vrijeme pridruživanja: kolovoz 2011.

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  1. Prikvačeni tweet
    16. svi 2017.
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  2. proslijedio/la je Tweet

    “We are not mascots. We are not fallen noble savages. Native Americans pass through airports. We serve in Congress. We take a stand against environmental destruction and cultural eradication. We fight for our children to stay within tribal communities.

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  3. 29. sij

    Seems like we have more days in the red though, non?

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  4. proslijedio/la je Tweet
    23. sij

    Congratulations to Dr. John Rolston, , and the entire epilepsy team ! Last week, they were the first in the world to use a mini-robot to place a closed-loop stimulator in a patient who suffers from epilepsy. – mjesto: Clinical Neurosciences Center - UUHC

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  5. proslijedio/la je Tweet
    23. sij

    So my uncle Wangchuk is a traditional Tibetan artist and he made this Tibetan thangka version of the cat meme.

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  6. proslijedio/la je Tweet
    22. sij

    Our paper supporting a theory first put forth in 1994 by Zohary et al. That suggested that correlations could limit information in large neural populations. Information limiting correlations in large neural populations

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  7. 21. sij
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  8. proslijedio/la je Tweet
    17. sij

    Turns out, action potentials in neurons that are recruited to the seizure become shorter in amplitude, and longer in duration (above), and that this is exclusive to the "core" of the seizure (anterior cingulate here). Check out the paper for full gif explanations... !

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  9. 19. sij

    Action potential gifs. ‘Nuff said. Check it out!

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  10. proslijedio/la je Tweet
    17. sij

    New showing the effects of epileptic seizures on individual human neurons, and what this means for our understanding of where seizures are actually happening:

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  11. proslijedio/la je Tweet
    13. sij

    Our free recall paper is finally out. Phys. Rev. Lett. 124, 018101 (2020) - Fundamental Law of Memory Recall

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  12. proslijedio/la je Tweet
    13. sij

    Very interesting! Microelectrode recordings are critical for such a fine scale analysis.

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  13. 13. sij

    These results further emphasize the importance of examining the high frequency LFP spectrum to contextualize seizure recordings in epilepsy research and point to broadband high frequency LFP's utility for understanding seizure mechanisms in the clinical setting.

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  14. 13. sij

    These analyses were inspired by work from 's lab and further confirm that broadening of the high frequency LFP spectrum is associated with increased population neuronal firing under an electrode, even if that electrode may not be able to record action potentials.

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  15. 13. sij

    Finally, back to that narrowband gamma, we show that action potentials measured on the microelectrode arrays differentially couple to narrowband gamma before and after the neuronal signature of recruitment into a seizure.

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  16. 13. sij

    We show this spectral broadening associated with seizing brain tissue can be clearly observed in the spectrum, or measured for each discharge in a seizure using information theoretic quantities.

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  17. 13. sij

    Note the clear narrowband gamma peak in the above spectrogram, and the increased broadband high frequency LFP after about 40 seconds. The narrowband gamma doesn't distinguish seizing brain tissue, but the broadening of the spectrum in later discharges does.

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  18. 13. sij

    First, early discharges are more broadly spatially distributed on ECoG, even more widespread than the later discharges that are associated with intense action potential firing, and phase-locked high frequency LFP that indicates seizing brain tissue.

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  19. 13. sij

    In this preprint, we used microeletrode array and ECoG recordings of human seizures to contextualize the clinically used LFP with action potential recordings. Can we see differences that would imply early inhibitory discharges?

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  20. 13. sij

    This has important implications for interpreting EEG for clinical purposes, as early discharges are often used to understand where the seizure is coming from. However inhibitory discharges are more of a response to a seizure elsewhere, rather than under the observed electrode.

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  21. 13. sij

    There are a bunch of studies in brain slices (picture from Trevelyan et al. 2007) showing that some of these early discharges are inhibitory.

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