a few: - uneconomical (you can't run a one-car train) - heavier = expensive track maintenance - very loud to stand near
also: - slower acceleration & braking - can't run if loco breaks down (whereas 1~2 MUs could break down w/o stopping train)
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also: - slower acceleration & braking - can't run if loco breaks down (whereas 1~2 MUs could break down w/o stopping train)