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dbasanta

  1. More Canoll insights: in a stem cell bases hierarchy, cancer cells are the rebellious ones in it... #BONK
  2. @parkerjo08 @cancerconnector thanks!
  3. That evidence comes from an experiment he suggested to a biologist at UCL #BONK
  4. Jacob thinks the second hypothesis makes more sense in light that cancer sc migrate to where there's cell death #bonk
  5. 2) death affects the ratio of symmetric cell division in stem cells thus leading to more nasty cancer stem cells #BONK
  6. Resistance happens. Why? 1) cancer stem cells are less radio sensitive #BONK
  7. What is a stem cell? Does not matter but it has the CD133 marker #BONK
  8. @CancerConnector and his continuum model of glioblastoma #BONK
  9. @CancerConnector 's time to talk about stem cells #BONK
  10. @gliomath not game theory this time but I could that other time! #BONK
  11. Pseudo hypoxia suggests that if we normalize o2 levels in the tumour the cells will behave as if they were in hypoxia #BONK
  12. @ara_anderson @CancerConnector @rrockne @gliomath could be? They upregulate hypoxia pathways = more VEGF?
  13. Pseudo hypoxia, some glioma cells upregulate hypoxia related pathways even when in normal oxygen levels #BONK
  14. Peter Canoll suggests that in older individuals the cells that remain have been selected to tolerate that stress #BONK
  15. Older cells tolerate low oxygen better. They tolerate stress a lot better. #BONK
  16. This morning's speaker #bonk neurosurgery.washington.edu/research/labs/… twitter.com/dbasanta/statu…
  17. Animal models like mouse models are nice but given their life expectancy we are talking about teenage tumours #BONK
  18. Not not incidence increases with Tim but malignancy too and obviously survival rates decrease #BONK